Clinical Efficacy Of Jiedu Huoxue Yuyang Decoction Combined With Kuijie Enema In The Treatment Of Mild And Moderate Ulcerative Colitis

Objective : To observe the clinical efficacy of jiedu Huoxue Yuyang decoction combined with Kuijie enema in treating dampness and heat accumulation,Qi stagnation and blood stasis in the active period of mild and moderate ulcerative colitis,and to evaluate objectively its efficacy and safety.Methods : 80 cases of mild and moderate ulcerative colitis in active stage were selected from the out-patients and inpatients of spleen and stomach diseases department of Shanxi University of traditional Chinese Medicine.The data of 80 cases with mild to moderate ulcerative colitis in active stage were studied by randomized controlled trial,which included damp-heat accumulation,qi stagnation and blood stasis.They were divided into treatment group and control group.On the basis of lifestyle intervention,the treatment group was given jiedu Huoxue Yuyang decoction orally combined with retention enema of ulcerative enema,while the control group was given sulfasalazine tablet oral combined with tin powder retention enema.4 weeks was a course of treatment.After one course of treatment,the clinical symptoms of the two groups were observed before and after treatment,and the results of colonoscopy were analyzed and compared in combination with statistical methods.The clinical symptoms,safety and recurrence of mild to moderate ulcerative colitis in the active stage of qi stagnation and blood stasis were evaluated by comprehensive evaluation of jiedu Huoxue Yuyang decoction combined with Kukejie Lavage decoction in the treatment of dampness-heat accumulation and qi stagnation and blood stasis in active stage of ulcerative colitis.Results:After the treatment group and control group,the results showed:(1)There were significant differences in abdominal pain,purulent blood stool,diarrhoea,internal acute weight,anal burning,erzia and malocclusion of skin before and after treatment in the treatment group.There was no significant difference in chest and flank distension.In the control group,there were significant differences in abdominal pain,purulent blood stool,diarrhoea,internal acute weight,anal burning and skin nail error before and after treatment,but there was no significant difference in Dezia red and chest and flank distension.(2)There were significant differences between the treatment group and the control group in defecation frequency,purulent blood stool,endoscopic manifestation and physician evaluation before and after treatment.(3)The total clinical effective rate in the treatment group was 94.74%,and in the control group,the clinical response rate was 94.74%.The total effective rate of bed was 75.68%.There was significant difference in clinical symptom score between the two groups(P < 0.05).(4)Improvement of clinical efficacy:in the treatment group,the clinical effective rate was 92.11%,the clinical remission rate was 21.05%,the endoscopic response rate was 71.05%,and the mucosal healing rate was94.74%.In the control group,the clinical response rate was 56.76%,the clinical remission rate was 5.41%,the endoscopic response rate was 37.84%,and the mucosal healing rate was 72.97%.It is suggested that the therapeutic effect of the treatment group and the control group is significant.(5)Recurrence assessment: 8 weeks after withdrawal,the recurrence of the treatment group was not statistically significant,but 12 weeks after the withdrawal,the recurrence was statistically significant compared with the end of the treatment.The recurrence of the patients in the control group after 8 weeks and 12 weeks were statistically significant compared with those at the end of the treatment.(6)Safety assessment: 92.5% of the patients in the treatment group had no adverse reactions.There was no adverse reaction in 77.5% of the patients in the control group.The rank sum test showed that there was a significant difference in the safety assessment between the treatment group and the control group(P < 0.05),and there was no significant difference between the treatment group and the control group(P < 0.05).Conclusion :(1)the clinical effective rate and TCM syndrome of jiedu Huoxue Yuyang decoction combined with Kuijie irrigation prescription in the treatment of mild to moderate ulcerative colitis are remarkable.(2)jiedu Huoxue Yuyang decoction combined with Kuijie enema recipe is effective in improving the number of stool,purulent stool,endoscopic manifestation and physician evaluation.(3)jiedu Huoxue Yuyang decoction combined with Kuijie decoction has obvious advantages in reducing recurrence rate and prolonging recurrence cycle.(4)jiedu Huoxue Yuyang decoction combined with Kuijie decoction is safe in the treatment of mild to moderate ulcerative colitis.