Study On Risk Factors Associated With First Acute Cerebral Infarction With Renal Impairment

Objective: Studies have reported a correlation between acute cerebral infarction and the occurrence of renal impairment,but there are few studies on the related risk factors between the two.In this study,serum cystatin C was used as an index to evaluate renal function in patients,and to explore the risk factors associated with renal dysfunction in patients with first acute cerebral infarction and its three types of TOAST classification(LAA,CE,SAA).I hope to provide a basis for early detection and prevention of impaired renal function.Methods:The first acute cerebral infarction patients admitted to the Department of Neurology,Second Hospital of Hebei Medical University from February 2017 to December 2018 were selected according to TOAST classification(LAA type,CE type,SAA type),a total of 305 patients.The patient’s general clinical data,laboratory indicators,and related auxiliary examinations were collected.The related risk factors were analyzed by single factor analysis and multivariate logistic regression.The data were analyzed and processed by SPSS21.0 statistical software.Results:1.This study included a total of 305 patients with first-episode acute cerebral infarction,including 100 cases of renal dysfunction,accounting for 32.79%.The results of single factor analysis showed that the differences of age,hypertension,diabetes,coronary heart disease,Hcy,hs-CRP were statistically significant(P < 0.05).After adjusting for relevant confounding factors,logistic regression analysis showed that there was a statistically significant difference in age,hypertension,diabetes,Hcy,and hs-CRP(P<0.05),which were independent risk factors for patients with first-episode acute cerebral infarction complicated with renal impairment.2.There were 123 cases of LAA type and 41 cases of renal function injury,the incidence rate was 33.33%.The results of single factor analysis showed that the differences of age and diabetes were statistically significant(P<0.05).After correction for related confounding factors,logistic regression analysis showed that the differences in age and diabetes were statistically significant(P<0.05),which were independent risk factors for LAA-type patients with renal impairment.3.There were 43 cases of CE type,including 17 cases of renal function injury,the incidence rate was 39.53%.The results of single factor analysis showed that the age difference was statistically significant(P<0.05).After correction for related confounding factors,logistic regression analysis showed that the age difference was statistically significant(P<0.05),which was an independent risk factor for CE-type patients with renal impairment.4.There were 139 SAA patients with 42 cases of renal function injury,the incidence rate was 30.22%.The results of single factor analysis showed that the differences of Hcy and fasting blood glucose were statistically significant(P<0.05).After correction for related confounding factors,logistic regression analysis showed that the difference of Hcy was statistically significant(P<0.05),which was an independent risk factor for SAA-type patients with renal impairment.Conclusion:1.Age,hypertension,diabetes,Hcy,hs-CRP are associated with the occurrence of renal dysfunction in patients with first-episode acute cerebral infarction;2.Age,diabetes are associated with the occurrence of renal dysfunction in LAA-type patients;3.Age is associated with the occurrence of renal impairment in CE-type patients;4.Hcy is associated with the occurrence of renal dysfunction in SAA-type patients.