Neuroprotective Effects Of Different Mild Hypothermia Treatments On Acute Severe Ischemic Stroked

Objective Neuroprotective therapy is one of the important approaches in the rescue treatment of acute severe ischemic stroke,and hypothermia has been shown to be an effective neuroprotective approach.This study investigated the neuroprotective effects of mild hypothermia against acute severe ischemic stroke,and identified the differences between two kinds of mild hypothermia therapy.We may provide a basis for clinical application of mild hypothermia therapy in patients with acute severe ischemic stroke.Methods A total of 52 patients with acute severe ischemic stroke admitted to our department of neurology in intensive care unit(NICU)were enrolled from January 2017 to February 2018.The basic data of each patient had no differences in gender ratio,underlying disease,severity of illness,vital signs.We divided these 52 patients into three groups,including the standardized medical treatment group(group A),the mild hypothermia therapy apparatus +standard medical treatment group(group B),and ALLON temperature control system +standard medical treatment group(group C).The three groups were performed the National Institutes of Health Stroke Scale(NIHSS)score and Electroencephalogram(EEG)in the 1st and 14 th days.The 14 th days and 1-month follow-up patients’ stroke outcomes(Modified Rankin Scale,mRS)score.Calculate the mortality rate of three groups of patients at 3months,and compare the differences between the three groups.Results 1.On the first day of admission,the NIHSS scores of the three groups were 31.67±4.45,33.6±3.9,and 32.07±4.8,respectively.we did not observed the significant difference,P>0.05.and there were no significant differences in EEG grading between the three groups of patients,P>0.05.2.The vital signs of patients in groups A,B and C before and after treatment: respiratory(R),heart rate(HR),blood pressure(MAP),and we did not observed the significant difference,P>0.05.3.The time reached the target temperature in groups B or C was 367.33±82.85 min or251.33±49.26 min respectively.The time reached the target temperature for the group C was shorter than that of the B group,and we observed the significant difference,P<0.001.4.The NIHSS scores of group A,B,and C on the 14 th day of admission were 29.4±5.77 in group A,25.3±4.58 in group B,and 21.53±4.0 in group C.The difference between the three groups was statistically significant,P<0.05.and we observed the significant difference between the B group and the C group,P<0.05;the mRS score on the 30 th day,A,B,C were4.27±0.80,3.73±0.59,3.6±0.51,respectively,and the difference between the three groups was statistically significant,P<0.05.5.In each group of patients,the EEG grading on the 14 th day was lower than that on the 1st day,and at 14 th days,the EEG grading of the B and C groups was significantly different from that of the A group,P<0.05.6.The mortality rates of the three groups of patients were 33.3%,26.7%,13.3%,the difference was not statistically significant,P>0.05.Conclusion 1.After the occurrence of acute severe ischemic stroke,two different methods of hypothermia are effective in improving neurological function and prognosis.2.The feasibility of mild hypothermia therapy in the treatment of acute severe ischemic stroke:In this study,Compared with the control group,patients receiving hypothermia had no significant differences in complications such as pulmonary infection and electrolyte imbalance;and there were no significant differences in vital signs between the two groups in the sub-hypothermia group before and after treatment.The results suggest that hypothermia therapy is safe and feasible.3.Compared with the Mild hypothermia therapy apparatus,the ALLON body temperature control system had advantages in improving nerve function and prognosis,and the time taken to reach the target temperature is shorter,which is more promising in the treatment of hypothermia.