| Objective:To observe the clinical curative effect of sleep quality and motor symptoms of Parkinson’s disease by using the method of nourishing blood,eliminating wind and soothing spirit.This study can evaluate the clinical efficacy and safety of traditional Chinese medicine syndromes scale(TCM)for the treatment of this disease and develop the thinking of TCM treatment.It also can provide real and effective clinical evidence for the treatment of this disease by integrated Chinese and western medicine.Methods:From March,2018 to December,2018,56 patients with Parkinson’s insomnia were enrolled in this study.All the patients came from The outpatient and inpatient departments of the Department of Encephalopathy,affiliated Hospital of Jiangxi University of traditional Chinese Medicine.They were randomly divided into treatment group and control group,28 cases in each group.The control group continued to add eszopiclone tablet on the basis of routine anti-Parkinson disease western medicine.the treatment group On the basis of taking routine western medicine and taking eszopiclone tablet,and add self-made Chinese medicine according to this method.15 days as a course of treatment,a total of two courses of treatment.Among them,Unified activities of daily life and exercise check-up section of Parkinson’s(UPDRS-Ⅱ,UPDRS-Ⅲ),Pittsburgh sleep quality Index scale(PSQI),Treatment emergent symptom scale(Tess)were evaluated once before treatment and 30 days after treatment.The Parkinson’s disease sleep scale(PDSS)and the Epworth sleepiness scale(ESS)were evaluated once for each assessment before treatment,15 days after treatment,and 30 days after treatment,respectively.The statistical results of the two groups were analyzed.Results:1.There was no significant difference in sex,age,course of disease and H-Y grade between treatment group and control group(P>0.05).The datas had comparability of the two groups,so we could analyse other datas.2.In the comparison of PDSS、ESS,the scores of PDSS were not obviously distinct improvement between the treatment group and the control group after 15 days of treatment,and there was no significant difference between the two groups(P>0.05).After 30 days of treatment,Parkinson’s sleep quality score in the treatment group was significan tly improvement than that before,the difference was statistically significant(P<0.01),and the effect was better than that in the radiation group(P<0.05).The effect of ESS scale was not obvious after 15 days in two gruops(P>0.05).After 30 days later,the daytime sleepiness score in pretherapy were significantly inferior to those before treatment and control group,there were statistical significance(P<0.05).The quality of sleep and daytime lethargy in the treatment group were significantly improved than those in the control group.3.In terms of PSQI scale,the sleep quality index in the post-treatment of treatment group decreased more significantly than prethera py after 30 days,with significant statistical significance(P<0.01),the effect was also superior to the control group,the difference was statistically significant(P<0.05).4.Comparing the scores of UPDRS-Ⅱ,the treatment group was decreasingg significantly than prior treatment(P<0.01).The difference was also statistically significant for comparing with the two groups(P<0.05).The scores of UPDRS-Ⅲ were decreased both within and between groups after treatment,and the effect of treatment group was better than that of control group(P<0.05).5.The scores of traditional Chinese medicine syndromes scale(TCM)in the two groups were all decreased after 30 days of treatment,and the scores of treatment group significantly tented downward than in the control group(P<0.05).The scores in the treatment group decreased significantly after treatment(P<0.05),while the scores of TCM in the control group did not improve significantly before and after treatment(P<0.05).6.In the Curative effect of insomnia in TESS before and after treatment of two groups,After 30 days of treatment,the total effective rate of the treatment group was 71.43%,and the other group was 39.29%,P=0.008,P<0.01.The results showed that the treatment group could obviously ameliorate the patient’s insomnia symptom.7.Throughout the clinical study,none of the patients showed any discomfort or adverse reactions,and the vital signs were stable before and after treatment,and all monitoring indicators were normal.Conclusion:In the treatment of Parkinson’s insomnia with the method of nourishing blood,eliminating wind and soothing spirit all the evaluation indexes of the patients were improved,the sleep quality of the patients was improved,the total sleep time was prolonged,the times of awakening and the abnormal sleep were also decreased.The patients with Parkinson’s disease also have improved self-care ability and motor symptoms,the safety is good,its clinical effect is worthy of recognition. |
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