| Objective To observe the clinical symptoms,gastroscopy and pathological effects of Yu Jin Mianjian Granule in the treatment of chronic atrophic gastritis,and to explore an effective clinical program for the treatment of chronic atrophic gastritis.Methods 1 Eighty patients with chronic atrophic gastritis diagnosed by gastroscopy and pathology from November 2017 to November 2018 in the hospital and outpatient department of the Affiliated Hospital of North China University of Technology were selected as the subjects of study.All the participants were randomly divided into two groups.There were 33 cases in the experimental group and 32 cases in the control group.The patients with Hp infection were treated with eradication of Hp(all of them were given rabeprazole sodium enteric-coated capsule 20 mg,furazolidone tablet 100 mg,bismuth potassium citrate 0.6g,amoxicillin capsule 1.0g,twice a day for 14 days).If there is no Hp infection,it will enter the test directly.In the experimental group,the specific medication method: 0.35 g Yu Jin Decoction-free granules were soaked in 30 ml boiling water twice a day for 24 weeks.The control group was given symptomatic treatment according to clinical symptoms.One case in the experimental group and two cases in the control group were excluded.2 Collect patients’ age,sex,course of disease,family history of gastric cancer,Hp infection,smoking history and drinking history.Record the clinical symptoms before and after treatment.Histopathological changes of gastric mucosa were recorded before and after treatment.The gastroscopic manifestations were recorded before and after treatment.The adverse reactions were recorded.3 All patients signed the Informed Consent of Digestive Endoscopy in the Affiliated Hospital of North China University of Technology before gastroscopy.4 All the data collected were input by Excel and the database was established.The data were analyzed by SPSS17.0 statistical software package.The main statistical indicators were tested for normality.Normal distribution measurements were expressed as mean(+standard deviation).T-test was used to compare the mean of age and integral between the two groups.Counting data were compared by Chi-square test between the two groups.The composition ratio of different factors and the difference of improvement rate of each index between the two groups after treatment.P<0.05 was statistically significant.Results 1 There was no significant difference in age,sex,Hp infection,smoking history,drinking history and family history of gastric cancer between the two groups(P > 0.05);there was no significant difference in symptom score,gastroscopy score and pathological score between the two groups before treatment(P>0.05).2 In the comparison of the improvement of symptoms,the improvement rate of the Wenyujin Mianjian Granule group was 89.7%,higher than another group’s improvement rate,and,this difference was significant(P<0.05).3 The improvement rate of gastroscopy in the Wenyujin Mianjian Granule group was 76.9%,higher than another group’s improvement rate,and P<0.05.4 The improvement rates of gland atrophy and atypical hyperplasia in the experimental group were 67.9% and 70.0% respectively,which were higher than those in the control group(P<0.05).In the comparison of intestinal metaplasia improvement rate,there was no significant difference between the experimental group and the control group(P>0.05).There was no significant difference between the two groups in the improvement of mucosal inflammation(chronic inflammation and active inflammation)(P>0.05).Conclusions 1 Yu Jin Decoction-free granule could reverse to some extent the atrophy of the inherent glands and atypical hyperplasia of gastric mucosa,but had no significant effect on the reversion of intestinal metaplasia and the improvement of gastric mucosal inflammation.2 Yu Jin Decoction-free granule could improve the roughness of gastroscopic mucosa and vascular permeability in CAG patients to a certain extent.3 Yu Jin Decoction-free granules could effectively improve the clinical symptoms of CAG patients.Figure5;Table14;Reference 118. |
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