Study On The Effects Of Medical Abortion In Early Pregnancy

Background Mifepristone has been applied on terminating of early pregnancy in clinic.However,there is still incomplete abortion,continuing pregnancies and vaginal bleeding after abortion.Therefore,it is the main direction of clinical research to explore the relevant factors which affect the termination of early pregnancy outcomes and the specific mechanism,and to improve the successful rate of medical abortion.Objectives By studying the relevant factors which affect the termination of early pregnancy outcomes and the specific mechanism of parity on abortion outcomes,and oral contraception(Yasmin)reduce vaginal bleeding after medical abortion.Providing new ideas and methods for improving the success rate of termination of early pregnancy.Methods In this study,who require to terminate pregnancy in our hospital were enrolled for information registration and telephone follow-up from January 2016 to June 2017.On the one hand,samples of villus are researched for relevant apoptosis factor immunohistochemistry detection.On the other hand,who experienced medical abortion use combine oral contraception(COC),follow-up of vaginal bleeding time and medical abortion outcome Results(1)Survivin expression in parous villi is higher than in primipara.(2)After oral mifepristone,the expression of Bax,Bcl-2 and survivin were enhanced in the villi of early pregnant women.(3)Comparision adding medical Yasmin with control group,Yasmin can decrease vaginal bleeding and the increase the success rate of abortion.Conclusion(1)Higher expression of survivin in parous villi tissue may lead to an increase in the failure rate of primipara women.(2)Mifepristone can promote cell apoptosis by enhancing the expression of Bax and inhibiting the expression of Bcl-2 and survivin,so as to terminate the early pregnancy.(3)Immediate oral Yasmin after termination of early pregnancy can effectively reduce the vaginal bleeding time and improve the success rate of medical abortion.