Correlation Of Radiotherapy With The Prognosis Of Elderly Patients With Breast Cancer

Objective:The present study examined the effect of radiotherapy on recurrence and survival in elderly patients with hormone-receptor-positive early breast cancer.Methods:A retrospective analysis of 327 patients aged ≥65 years with stage I-II,hormone receptor positive breast cancer who underwent breast conserving surgery and received endocrine therapy(ET)or radiotherapy plus endocrine therapy(ET+RT)was performed.Both groups were divided into luminal A type and luminal B type subgroups.Evaluation criteria were 5-year disease free survival(DFS),local relapse rate(LRR),overall survival(OS),and distant metastasis rate(DMR).Results:The 5-year DFS rates were 69.8% in the ET group and 76.1% in the RT+ET group.There were significant differences in DFS between the two groups at 5years.In luminal A type,there was no significant difference in the 5-year DFS between the ET group and the RT +ET group.In luminal B type,the 5-year DFS differed significantly between the ET group and RT +ET group.In the ET group,there were significant differences in the 5-year DFS between luminal A type and luminal B type.The 5-year LRR rates were 8.9% in the ET group and 3.0% in the RT+ET group.There were significant differences in the LRR between the two groups at5 years.In luminal A type,there was no significant difference in the 5-year LRR between the ET group and the RT +ET group.In luminal B type,the 5-year LRR differed significantly between the ET group and the RT +ET group.No significant difference in LRR was observed in the ET group.The 5-year OS rates were 80.0% in the ET group and 77.0% in the RT +ET group.There were no significant differences in the 5-year OS between the two groups.The 10-year predicted OS rates were 30.0%in the ET group and 50.0% in the RT +ET group,and the difference was not statistically significant(HR: 1.10,95% CI 0.69–1.75,P = 0.6911).In luminal A type,there was no significant difference in the 5-year OS between the ET group and the RT+ET group.In luminal B type,the 5-year OS differed significantly between the ET group and the RT +ET group.In the ET group,there were significant differences in5-year OS between luminal A type and luminal B type.The 5-year DMR rates were2.5% in the ET group and 2.7% in the RT +ET group.There were no significant differences in 5-year DMR between the two groups.In luminal A type,there was no significant difference in the 5-year DMR between the ET group and the RT +ET group.In luminal B type,there was no significant difference in 5-year DMR between the ET group and the RT +ET group.In the ET group,there were no significant differences in 5-year DMR between luminal A type and luminal B type.Conclusions: After breast breast-conserving surgery,radiotherapy can reduce the LRR and improve the DFS and OS of luminal B type elderly patients,whereas luminal A type elderly patients do not benefit from radiotherapy.Without radiotherapy,luminal A type patients have better DFS and OS than luminal B type patients.