Study Of Cerebral Hemodynamics In Patients With Chronic Mountain Sickness By Magnetic Resonance Perfusion Imaging

Objective:To study the changes of cerebral hemodynamics in patients with chronic mountain sickness,using magnetic resonance perfusion imaging technique.Methods:Twenty patients with chronic mountain sickness and 18 normal volunteers(control group)were collected.Phillips 3.0T magnetic resonance imaging was used to perform routine head sequence and PWI examination.In the post-processing software,the middle cerebral artery,white matter of frontal lobe,head of caudate nucleus,knee of corpus callosum,splenium of the corpus callosum,dorsal thalamus and hippocampus were selected as regions of interest,and the perfusion parameters of different regions of interest(rCBF,rCBV,MTT and TTP)were obtained.The perfusion parameters were analyzed and at the same time the parameters of ROI on both sides of the same site were analyzed,too.Results:Compared with normal volunteers,the rCBF of middle cerebral artery in CMS group decreased(P<0.05),MTT and TTP prolonged(P<0.01);the rCBF of splenium of the corpus callosum in CMS group decreased(P<0.05),rCBV and TTP shortened(P<0.05);the rCBF of knee of corpus callosum and TTP prolonged(P<0.05)in CMS group.The rCBF of bilateral frontal white matter shortened and TTP prolonged(P<0.05)in CMS group;the rCBF of bilateral caudate nucleus head decreased(P<0.05),MTT and TTP prolonged(P<0.05);the rCBF of bilateral thalamus in CMS group decreased and TTP prolonged(P<0.01),and MTT of right thalamus prolonged(P<0.05);TTP of bilateral hippocampus in CMS group prolonged(P<0.01),and MTT of right hippocampus prolonged(P<0.05).2.In CMS group,only the MTT value in right hippocampus increased compared with that in left hippocampus(P<0.05);in normal volunteers,merely the rCBV and MTT value in right thalamus decreased compared with that in the left(P<0.05).Conclusions:There are collateral circulation compensation in the brain of patients with chronic mountain sickness;The cerebral hemodynamics between CMS patients and normal group have differences;Magnetic resonance perfusion imaging is of great significance for the diagnosis and further study of chronic mountain sickness.