Comparison Of Efficacy Of Sufentanil And Oxycodone On Catheter-related Bladder Discomfort In Trans-urethral Resection Of The Prostate

Objective:To compare the efficacy of sufentanil and oxycodone on predicting catheter-related bladder discomfort in trans urethral resection of the prostate and discover its suitable dosage.Method:Totally 120 male patients having a selective operation of trans-urethral resection of the prostate under general anesthesia from January to October 2018 in the First Affiliated Hospital of China Medical University were chosen,randomly devided into 4groups,sufentanil S₁ group(0.06μg·kg^-1)and S₁ group(0.12μg·kg^-1),oxycodone O₁ group(0.06mg·kg^-1)and O₂ group(0.12mg·kg^-1),with 30 patients each group.During anesthesia induction,we gave midazolam(0.02mg·kg^-1),sufentanil(0.5μg·kg^-1),cisatracurium(0.2mg·kg^-1),etomidate(0.2mg·kg^-1)by intravenous injection,and the maintenance of anesthesia with sevflurane and propofol.The drug administration was accomplished at 15min before the end of the operation,observing and recording MAP,HR,Ricker score and Ramsay score before the surgery and after extubation 0 min,15min,30min.The VAS score,the occurrence rate of CRBD and its severity were recorded after extubation 0 min,15min,30min,3h and 6h.The adverse reactions within 6h after operation were also observed.Result:1.After 15min,30min,3h and 6h of the extubation,the occurrence rate of CRBD was reduced obviously in oxycodone（O₁,O₂）group compared with equivalent dose in sufentanil（S₁,S₂）group（P<0.05）.For severity of CRBD,the occurrence rate of moderate and severe CRBD in oxycodone（O₁,O₂）group was lower than sufentanil（S₁,S₂）group after 3h and 6h of the extubation（P<0.05）.2.The HR was descended in O₂group than S₂ group（P<0.05）,the hemodynamic change was smaller in O₂ group.3.The VAS score was lower in O₂ group than S₂ group after 15min and 30min of the extubation（P<0.05）,and also lower in oxycodone（O₁,O₂）group compared with equivalent dose in sufentanil（S₁,S₂）group after 3h and 6h of the extubation（P<0.05）.4.The Ricker scores were reduced in oxycodone（O₁,O₂）group compared with sufentanil（S₁,S₂）group respectively,and the Ramsay scores were higher in O₂ group rather than O₁ group（P<0.05）.5.The incidence rate of postoperative nausea and vomiting within 6h was higher in O₂ group rather than O₁ group（P<0.05）,but the defferences were no statistically significant between sufentanil and oxycodone group,and the defferences of other adverse effects were no statistically significant（P>0.05）.Conclusion:Compared with sufentanil,oxycodone is more effective treating catheter-related bladder discomfort,further more,oxycodone of 0.06mg·kg^-11 can achieve a satisfied curative efficacy with less adverse reaction.