| Objective:The purpose of this study was to compare the effects of different doses of oxycodone during anesthesia induction on hemodynamics and recovery time of patients undergoing transurethral resection of prostate to the inhibitory effect of early postoperative urinary cathetery-related bladder discomfort.Methods:A total of 46 patients underwent transurethral resection of the prostate from September 2020 to December 2020 in the General Hospital of China-Japan Friendship Hospital of Jilin University were selected.ASA class isⅡ ～ Ⅲ.According to random number table method,they were divided into O1 group and O2 group,with 23 cases in each group.Preoperative routine fasting,abstaining from water,without any preoperative drugs.The O1 and O2 groups were given 0.1mg/kg oxycodone and0.15mg/kg oxycodone,respectively,during induction.The other induction drugs in the two groups were cis atracurium 0.1mg/kg,propofol 1mg/kg,and etomidate0.1mg/kg.For maintenance,sevoflurane was inhaled 1%,and remifentanil was pumped 0.1-0.2ug/kg/min,and propofol was pumped 0.02-0.03mg/kg/min.Record before induction is T0;laryngeal mask into immediate is T1;the beginning of surgery is T2;the end of surgery is T3;removing laryngeal mask is T4;mean arterial pressure is MAP;heart rate is HR;pulse oxygen saturation is SPO2;electrical double frequency index is BIS.We observed whether the laryngeal mask placement would cause cough,or laryngeal mask bitten by teeth,and body movement or not;observed whether the removal of laryngeal mask would cause laryngospasm or not;recorded the time between the removal of the laryngeal mask and the end of the operation(time of awakening).Intraoperative maintained between 40 ～ 60 BIS index.The end-expiratory carbon dioxide remained 35～45mm Hg.The pumping rate of remifentanil and propofol can be adjusted according to the intraoperative hemodynamics of patients.VAS score after awakening,incidence and severity of catheter associated bladder irritation(CRBD),Ramsay sedation score,restlessness score,nausea,vomiting,respiratory depression,dizziness,pruritus and other adverse reactions,as well as intraoperative awareness and other adverse experiences in 2groups were observed and recorded.Results:There was no significant difference in general information and operation time between the two groups(P >0.05).There was no significant difference in MAP values between O1 group and O2 group at each time point from T0 to T4(P>0.05).Compared with T0,MAP index of each group at T1,T2 and T3 showed a decreasing trend(P <0.05).At each time point from T0 to T4,there was no statistically significant difference in HR index between the two groups(P >0.05).Compared with T0,T1,T2 and T3,HR showed a downward trend(P <0.05).There was no significant difference in VAS score between the two groups after laryngeal mask removal(1.00±0.43 VS 0.96±0.47)(P >0.05).There was no significant difference in the incidence and degree of urinary catheter-related bladder irritation between the two groups within 2 hours after surgery(P >0.05).The recovery time of O1 group was shorter than that of O2 group(4.91±2.23 min VS 8.17±3.49min),so the difference was statistically significant(P <0.05).No cough or body movement occurred in both groups when laryngeal mask was placed.No laryngeal spasm occurred after the laryngeal mask was removed.There was no significant difference in ADR between the two groups in the early postoperative period(P>0.05).No intraoperative awareness occurred in both groups.Conclusions:The induced dose of oxycodone both 0.1mg/kg and 0.15mg/kg can be safely applied to patients undergoing transurethral resection of prostate.The hemodynamics of the two groups are stable,and the incidence of cathetery-related bladder discomfort can be effectively inhibited in the early postoperative stage,with fewer adverse reactions and good analgesic effect.Patients receiving the induced dose of 0.1mg/kg can wake up more quickly. |
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