Clinical Trial Of Three Methods In Termination Of 14-16 Weeks’ Gestation

ObjectiveTo investigate the clinical safety and effectiveness of three different methods in termination of 14-16 weeks of pregnancy.One method is use mifepristone and misoprostol,One method is use mifepristone and combined with intra-amniotic cavity injection of Rivan-ol under the guidance of ultrasound,The other method is using mifepristone combined wi-th extra-amniotic cavity injection of Rivanol through vagina.MethodsAs a randomized comparative study,choosing pregnant women who correspond with our country’s basic policy of family planning and requesting to give up pregnancy dur-ing14-16weeks in Affiliated Hospital of Tai Shan Medical College from January 2014 to August 2015.Ninety and two cases which meet inclusion and exclusion criteria.These pre-gnant women are randomly divided into three observation groups.Group A(n=30,using mifepristone and misoprostol),group B(n=31,using mifepristone and combined with intra-amniotic cavity injection of Rivanol under the guidance of ultrasound),group C(n=31,using mifepristone and combined with extra-amniotic cavity injection of Rivanol through vagin-a).The clinical effectiveness of these three methods was evaluated through observe and compare the success rate of labor induction,the average time of abortion,amount of24h vaginal bleeding,side effects(Nausea,vomiting,diarrhea,fever,etc)and complications(soft birth canal laceration,infections,etc),amount of post-abortion curettage,the hospital-ization expenses,the hospitalization stay,the duration of vaginal bleeding after induced labor and the Time of menstruation turn over.ResultsThere was no statistically significant difference in the success rate of labor induction,(χ~2=0.46,P=0.79>0.05);There was no statistically significant difference in the 24h vaginal bleeding(F=1.77,P=0.18>0.05);There was no statistically significant difference in the hospitalization stay(F=1.64,P=0.20);There was no statistically significant difference in the side effects and complications(χ2=5.83,P=0.054>0.05);Compared with group B and C,the shorter average time of abortion,lower post-abortion curettagerate and less hospital-ization expenses were found in group A(P<0.05).The time from the begining of uterine contraction to the pregnancy product discharge of group A(6.40±2.36)h,group B(12.70±5.96)h,groupC(8.95±3.31)h,the difference was statistically significant(F=30.30,P<0.05);The post-abortion curettagerate in Group A(43.33%),group B(76.67%),group C(66.67%),the difference was statistically significan t(χ2=7.47,P<0.05);Average hospitallization expenses of group A(1569.71±261.90)yuan compared with group B(2583.47±267.19)yuan,group C(2562.02±375.17)yuan,the difference was statistically significant(F=107.55,P<0.05).Conclusion1.Mifepristone combined with Misoprostol in termination of 14-16 weeks of pregna-ncy are simple,safe,little pain of patients,inexpensive and worthy of widely clinical.2.Compared with using Mifepristone and Rivanol,Mifepristone combined with Miso-prostol works better in the termination of 14-16 weeks of pregnancy.