Analysis Of Polycyclic Aromatic Hydrocarbon Exposure Levels And Influencing Factors In Pregnant Women And Newborns

Objective:To understand the exposure status and influencing factors of polycyclic aromatic hydrocarbons（PAHs）in pregnant women and newborns in Urumqi through a combination of epidemiological investigations and laboratory tests,and to clarify the correlation between atmospheric pollutants and PAHs in pregnant women and newborns.Method:1.Take 100 pregnant women and their newborns during heating and non-heating periods in a general hospital in Urumqi as the research object,conduct epidemiological investigation and collect maternal venous blood and neonatal cord blood.2.Determination of 16 PAHs（naphthalene,pinene,pyrene,phenanthrene,phenanthrene,anthracene,fluoranthene,pyrene,benzo[a]pyrene）in maternal venous blood and neonatal umbilical cord blood by gas chromatography-mass spectrometry.Pyrene,benzo[g,h,i]pyrene,benzo[a]anthracene,benzo[b]fluoranthene,benzo[k]fluoranthene,indene[1,2,3,-cd]pyrene,Dibenzo[a,h]anthracene)content.3.Calculate the period of pregnancy during the pregnancy period based on the birth time of each pregnant woman and the period of pregnancy.Collect the air pollutant data during pregnancy and use the principal component analysis method to analyze the correlation between air pollutants and PAHs levels in pregnant women.Results:1.The 16 kinds of PAHs in venous blood of pregnant women during heating period（16.4±3.99）and the 16 kinds of PAHs（13.3±3.63）in venous blood of pregnant women during non-heating period were statistically significant（P<0.001）;The 16 types of PAHs in umbilical cord blood of newborns during heating period（14.09±3.22）and the 16 types of PAHs（11.48±3.28）in umbilical cord bloods of newborns during non-heating period were statistically significant（P<0.001）.2.Pyrene,naphthalene,benzo[a]pyrene,benzo[b]fluoranthene,dibenzo[a,h]anthracene and non-heating pyrene,naphthalene,benzo[a]in maternal venous blood during heating period Pyrene,benzo[b]fluoranthene,dibenzo[a,h]anthracene are statistically significant（P<0.001）;heating period fluorene,anthracene,fluoranthene,pyrene and non-heating in neonatal umbilical cord blood Periods of fluorene,anthracene,fluoranthene,and fluorene were statistically significant（P<0.001）.3.According to multiple stepwise regression analysis,it was found that the factors that affect the concentration of 16∑PAHs in maternal venous blood include heating methods during pregnancy,whether there are carpets,tapestries,whether eggs are eaten every day during pregnancy,and the age of pregnant women;it affects 16 kinds of umbilical cord blood in newborns.PAHs concentration factors include whether pregnant women eat eggs every day during pregnancy.4.Pyrene anthracene,benzo[a]pyrene,pyrene in PAHs in venous blood of pregnant women during heating period are related to PM_2.5.5 and PM₁₀,and benzo[a]pyrene in PAHs in venous blood of pregnant women during non-heating period,Benzo[b]fluoranthene and pyrene are correlated with PM_2.5.5 and PM₁₀.5.The cumulative total variance of PM_2.5.5 and PM₁₀0 in the atmosphere during the heating period reached 91.4%,and the cumulative total variance of the PM_2.5.5 and PM₁₀0 during the non-heating period reached 73.59%.Conclusion:Urumqi pregnant women and their newborns were exposed to multiple PAHs of varying degrees.Heating has the most obvious effect on maternal venous blood and neonatal cord blood PAHs,especially the exposure of atmospheric pollutants on the fluorene index will affect the level of maternal and neonatal PAHs.