Clinical Study Of Different Treatments For Family Aggregated Helicobacter Pylori Infection

Objective:To explore the economic and practical method of eradicating and treating family-aggregated Helicobacter pylori（H.pylori）infection.Methods:Through the ¹³C-UBT test,300 H.pylori-infected families who attended the Department of Gastroenterology,Cangzhou People’s Hospital from October 2017 to August 2018 were included and divided into a common treatment group（group A）and a separate treatment group according to the family wishes of the patients.The independent treatment group was randomly divided into a separate drug treatment group（group B）and a separate drug treatment + education intervention group（group C）.The number of households in groups A,B,and C was 92,104,and 104,respectively.Compare the eradication rate of H.pylori and the recurrence rate after 1 year in patients in groups A,B,and C.Results:1.The H.pylori infection rate of outpatients with stomach problems was 57.0%（535/938）.Among the 300 infected families,the H.pylori infection rate was as high as 76.1%（703/924）.All patients treated with medication returned to the hospital for a review of the ¹³C-UBT test after 1 month,with a response rate of 100%;15 cases were lost to follow-up after 1 year,with a response rate of 94.5%（259/274）.2.The H.pylori eradication rates of patients in groups A,B,and C were 94.6%,87.5%,and 92.3%,respectively,with no significant difference（P> 0.05）.3.The eradication rate of H.pylori in group A patients was 94.6%,and the eradication rate of family members was 85.9%.The difference between the two was statistically significant（P <0.05）.4.After successful eradication of H.pylori infection,the ¹³C-UBT test was re-examined 1 year after discontinuation,The recurrence rates of H.pylori in the three groups A,B,and C were 4.8%,18.6%,and 5.6%.There was a statistically significant difference between the single drug treatment group and the other two groups（P<0.0167）.There was no significant difference in recurrence rates between groups A and C（P> 0.0167）.Conclusion:1.Familial clustered H.pylori infection,drug alone and education intervention treatment can achieve approximately the same eradication rate and relapse rate as co-treatment.2.Multiple people in the family are infected with H.pylori,only a single member treats,the recurrence rate is high3.Family clustering H.pylori infection,the eradication rate of family members accompanying the treatment is low,and co-treatment does not show an advantage.If the combined education and intervention can achieve better results,further observation and research are needed.