Early Elevated Neutrophil-to-lymphocyte Ratio Associated With Remote Diffusion-weighted Imaging Lesions In Acute Intracerebral Hemorrhage

Objective To explore the relationship between the circulating neutrophil to lymphocyte ratio(NLR)and the remote diffusion weighted imaging lesions(R-DWILs)after spontaneous intracerebral hemorrhage(ICH).Methods Consecutive patients with spontaneous ICH were prospectively collected from November 2016 to May 2018 and retrospectively analyzed.We included sub jects who presented within 24 hours after symptom onset and were free of detectable infections on admission or in hospital.Blood samples were obtained at 24 48 hours after ICH ictus,while all complete MRI scans were performed at 5 8 days.R-DWILs were defined as focal hyperintensities remote from the site of the ICH or the peri he matoma regions.NLR was calculated by dividing the absolute neutrophil counts by the absolute lymphocyte counts.Multivariate binary logistic regression models were generated to evaluate the relationship between NLR and R-DWILs Results One hundred sixty three subjects met eligibility criteria(age 62.3 ± 13.6 years,60.7% males),of whom 31(19.0%)experienced R-DWILs.Higher circulating NLR was documented in patients with R-DWILs.With the best cutoff value of 6.01,elevated NLR was independently associated with the presence of R-DWILs(OR = 3.170,95%CI 1.306 7.697,=0.011)in the bivariate logistic regression analysis with adjustment for age,sex,atrial fibrillation,previous ischemic stroke/TIA,SBP on admission,hematoma volume,and IVH.Conclusions This study provides significant evidence of the association between circulating NLR and R-DWILs in spontaneous ICH patients.Patients with NLR > 6.01 at24 48 hours after ICH ictus showed a higher probability with R-DWILs.