| BackgroundPeripheral T-cell lymphoma(PTCL)is a highly heterogeneous non-Hodgkin lymphoma(NHL)subtype.To date,several prognostic models have been proposed to predict the prognosis of PTCL patients.However,the factors affecting PTCL prognosis are still not fully elucidated.Therefore,it is of great importance to seek the indicators associated with poor prognosis.MethodsA retrospective study of 213 adult patients with diagnosed PTCL in the First Affiliated Hospital of Medical School of Zhejiang University from January,2012 to December,2017 was performed.The aim is to assess the value of platelet-lymphocyte ratio(PLR)and neutrophil-lymphocyte ratio(NLR)in the treatment response and prognosis of PTCL patients.ResultsThe median age of all PTCL patients was 52 years.135 cases(63.4%,135/213)weremale and 78 cases(36.6%,78/213)were female.Patients with PLR≥232.5 achieved a lower complete response(CR)rate than patients with PLR<232.5(18.5%vs.56.6%,P<0.001).And the CR rate of patients with NLR≥3.7 was also significantly lower than that of patients with NLR<3.7(31.7%vs.60.7%,P<0.001).In the Cox univariate analysis,high PLR and high NLR were related with worse overall survival(OS).And Cox multivariate analysis suggested that PLR≥232.5,bone marrow involvement,IPI>2,decreased albumin level and ALC≤0.8×10~9/L were independent prognostic factors of PTCL patients.Then,all patients were divided into four groups according to the number of risk factors,including low risk group(zero,one or two factors),intermediate low risk group(three factors),intermediate high risk group(four factors)and high risk group(five factors),with the 3-year OS of 84.2%,41.9%,16.3%and 0.0%,respectively(P<0.001).ConclusionThis retrospective study demonstrated that high PLR and high NLR were closely associated with the treatment response and prognosis in patients with PTCL,which may improve the risk stratification and guide clinical treatment. |
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