| Objective This study mainly evaluated the clinical efficacy of Gutaiyin in improving symptoms of traditional Chinese medicine(TCM),the blood test values of progesterone(P)and β-human chorionic gonadotropin(β-HCG),uterine effusion,pregnancy outcome and other aspects in patients with early threatened abortion due to kidney deficiency,so as to provide data support for the advantages of traditional Chinese medicine in pregnancy preservation.Method To investigate the clinical symptoms of patients with threatened abortion by questionnaire,and investigate TCM syndrome score table that meets the inclusion and exclusion criteria from February 2017 to February 2019;They were randomly divided into the treatment group and the control group,with 48 cases in each group,a total of 96 cases.The treatment group was treated with Gutaiyin combined with progesterone,and the control group was treated with progesterone alone.The data included in the statistical analysis were compared between the two groups to compare the changes in symptoms such as lumbar acid and abdominal pain,vaginal bleeding,etc.,kidney deficiency score,blood test values of P and β-HCG,uterine cavity effusion by gynecological sonography,and pregnancy outcome and so on after treatment,to evaluate the clinical efficacy of Gutaiyin.Result A total of 96 cases were recruited in the study,with 5 cases with inevitable abortion,1 case did not follow the doctor’s advice,and finally 90 cases were rerolled.The pregnancy outcomes of 80 patients were finally followed up,and 10 patients lost follow-up due to personal reasons.1.The general data and the clinical data of the two groups before treatment were statistically analyzed,and the difference was not statistically significant,which was comparable(P>0.05).2.There was a significant difference in the comprehensive efficacy between the two groups after treatment(P<0.01),which was 95.56% in the treatment group and 86.67% in the control group.3.Each individual score and the total score of TCM syndromes in the two groups decreased After treatment,which was compared with that before,and there were significant differences in the scores before and after treatment in the two groups(P<0.01).And there were statistically significant differences in the total score of TCM syndromes and the single score of vaginal bleeding,lumbar acid swelling pain and alvine pendant pain between the two groups(P<0.05).There was a significant difference in the efficacy of TCM syndromes between the groups after treatment,which was 97.78% in the treatment group and 91.11% in the control group(P<0.01).4.There was a significant difference in the distribution of stop time of vaginal bleeding between the two groups after treatment(P<0.01),and the average time of the treatment group was shorter than that of the control group.5.The scores of kidney deficiency syndrome elements in the two groups decreased significantly after treatment,and there were significant differences between two groups(P<0.01).6.The uterine cavity effusion area of the two groups decreased after treatment compared with that before treatment,and there was a significant difference(P<0.01)between the treatment group,while there was no statistically significant difference(P>0.05).After treatment,the effusion area of the treatment group was significantly reduced compared with that of the control group,and the difference was statistically significant(P<0.05).7.The blood values of P and β-HCG in both groups were higher after treatment than before(P<0.05),and the values of β-HCG in the treatment group was significantly higher than that in the control group,with statistically significant differences(P<0.05).8.The rate of embryo arrest was 4.88%,and the final delivery rate was 95.12% in the treatment group,compared with 23.08% and 76.92% in the control group,the differences were statistically significant(P<0.05).9.During the treatment period,there was 5 patients presented pain at the injection site,with 3 patients in the control group and 2 patients in the treatment group,and 1 patient presented subcutaneous nodules,and all of them were able to continue their treatment after treatment.And the remaining patients were normal.Conclusion Gutaiyin not only has obvious efficacy in improving syndromes such as vaginal bleeding,lumbar acid,abdominal pain and so on,but also has efficacy in improving blood test values of P and β-HCG,uterine cavity effusion and other aspects.It can also reduce the rate of embryo arrest,improve pregnancy outcome.Generally speaking,the effect of Gutaiyin is good. |
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