Analysis Of Recurrence,Metastasis And Prognosic Factors In 96 Patients With Phyllodes Tumor Of Breast

Objective To explore the relationship between clinical features of patients with phyllodes tumor of breast(PTB)and reccurence,distant metastasis,and prognosis in retrospective analysis of a single center study.Methods The clinical data of 96 patients with PTB treated in this hospital from March 2011 to December 2018 were retrospectively analyzed.The correlation of clinical features with local recurrence and distant metastasis were analyzed by the Chi-square test and logistic regression.The Kaplan-Meier method was used to compute disease-free survival(DFS).The correlation of clinical features with prognosis was analyzed by the log-rank test and Cox regression.Results Ninety-four patients with PTB showed the unilateral single nodule,2 patients showed the bilateral nodules.All patients had surgery,postoperative pathology showed that the benign tumor had 36 patients,borderline tumor had 34 patients,malignant tumor had 26 patients.A total of 27 patients had local recurrence,4 patients had distant metastasis,4patients died during the follow-up period.The 1-,3-,and 5-yearaccumulate DFS rate was 81.2%,64.9%,and 64.9%,respectively.The accumulate 5-year overall survival rate was 92.3%.The multivariate analysis showed that the age,types of tumor,and surgical method were related to the local recurrence(P<0.050),and no clinicopathological factors were found to be related to the distant metastasis(P>0.050).It was found that type of tumor was the independent factor affecting prognosis(P<0.050).Conclusions Phyllodes tumou of breast is a rare neoplasm of the breast,the recurrence rate is higher,occur the distant metastases,such as lung,bone,brain and so on.The age and tumor types are the independent recurrent factors.Surgical treatment is the primary management,extend resection and mastectomy are alternative operation.