Clinical Features Of Peptic Ulcer Bleeding In Patients With Diabetes Mellitus

Objective: To study the clinical features of peptic ulcer bleeding in patients with diabetes mellitus,and to provide clinical ideas for the specific treatment of peptic ulcer bleeding in patients with diabetes mellitus.Methods: A retrospective analysis method was used to collect 102 patients with peptic ulcer bleeding associated with diabetes as subjects.Those patients were admitted to the Department of Gastroenterology,Shanghai Sixth People’s Hospital from January 2013 to December 2018.At the same time,102 patients with simple peptic ulcer bleeding matched by general data such as gender and age were used as controls.Gastrointestinal symptoms,ulcer type,Hp infection,Hp eradication,laboratory parameters,hospital stay,and in-hospital mortality were compared between the two groups.Perform statistical analysis.Results: 1.Gastrointestinal symptoms: The observation group had more abdominal distension than the control group,the difference was statistically significant(P<0.05),and the patients with abdominal pain symptoms were less than the control group,the difference was statistically significant(P <0.05).There were no significant differences between the two groups in patients with nausea,vomiting,acid reflux,hernia,and diarrhea(P>0.05).2.Types of ulcers: The incidence of gastric ulcer and compound ulcer in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05),and the incidence of duodenal ulcer was lower than that in the control group.The difference was statistically significant.(P<0.05).3.Hp infection: There was no significant difference in Hp infection rate between the observation group and the control group(P>0.5).The observation group was divided into three groups according to the different course of diabetes: the disease course <5 years,the disease course 5 years to 10 years,and the disease course >10 years.There was no significant difference in Hp infection rate between the three groups(P>0.05)..The observation group was divided into two groups according to the different levels of glycated hemoglobin: glycated hemoglobin≥7 and glycated hemoglobin<7.There was no significant difference in Hp infection rate between the two groups(P>0.05).4.Hp eradication: There was a difference in Hp eradication rate between the observation group and the control group(P<0.5).The observation group was divided into three groups according to the different course of diabetes: the disease course <5 years,the disease course 5 years to 10 years,and the disease course >10 years.There was no significant difference in Hp eradication rate between the three groups(P>0.05).The observation group was divided into two groups according to the different levels of glycated hemoglobin: glycated hemoglobin≥7 and glycated hemoglobin<7,and the Hp eradication rate of the two groups was different(P<0.05).5.Laboratory indicators: The hemoglobin level and albumin level in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05);the ratio of hemoglobin<70g/l and albumin<30g/l were higher than the control group,the difference was statistically significant(P<0.05).6.Hospitalization time: The number of hospital stays in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).In-hospital mortality: There was no significant difference between the two groups(P>0.5).Conclusion: Compared with patients with simple peptic ulcer bleeding,the incidence of abdominal pain is lower in those patients with peptic ulcer bleeding associated with diabetes,and the incidence of abdominal distension is higher;the incidence of gastric ulcer and compound ulcer is higher,and the incidence of duodenal ulcer is lower;the Hp eradication rate is lower;the higher the HbAlc is,the lower the Hp eradication rate is;the hemoglobin level and albumin level are lower,the hemoglobin <70g/l ratio and the albumin <30g/l ratio are higher;and the hospital stay is longer.Peptic ulcer bleeding in patients with diabetes mellitus has its own characteristics,based on the principle of treatment of simple peptic ulcer bleeding,these differences should be considered in the treatment to develop a specific treatment plan.