Correlation Between Plasma NT-probnp And Cys-c Levels And Acute Ischemic Stroke

Objective: To investigate the relationship between plasma N-terminal pro brain natriuretic peptide(NT-proBNP),Cystatin C(Cys-C)levels and the occurrence of acute ischemic stroke(AIS),infarct size and the degree of neurological deficit,and to further analyze their related influencing factors and their relationship with each other.Methods: From January 2018 to June 2019,89 first-acute ischemic stroke patients admitted to the Affiliated Hospital of Hebei Engineering University were selected as the case group,and 88 healthy people were selected as the control group.The plasma NT-proBNP and Cys-C levels were detected and compared between the case group and the control group.According to the infarct size,the case group was divided into largearea infarction,medium-area infarction and small-area infarction.According to the National Institute of Health stroke scale(NIHSS),the case group was divided into the severe group and the mild group.The plasma NT-proBNP and Cys-C levels were compared between different infarct size groups and different NIHSS score groups.Pearson or Spearman correlation was used to analyze the correlation between plasma NT-proBNP,Cys-C levels and other clinical indicators.Logistic regression was used to analyze the relationship between plasma NT-proBNP,Cys-C levels and the occurrence of AIS.Results:1.The factors of smoking history,hypertension history,diabetes history,age,total cholesterol,low density lipoprotein,lipoprotein(a)and plasma NT-proBNP,Cys-C levels in the case group were significantly higher than those in the control group(P<0.05).2.The plasma NT-proBNP,Cys-C levels in the large-area infarction group were significantly higher than those in the medium-area infarction group(P <0.05),and plasma NT-proBNP,Cys-C levels in the medium-area infarction group were significantly higher than those in the small-area infarction group(P <0.05).3.The plasma NT-proBNP levels in the severe group was significantly higher than that in the mild group(P <0.05).However,there was no significant difference in plasma Cys-C levels between the severe group and the mild group(P <0.05).4.The plasma NT-proBNP,Cys-C levels in patients with AIS were positively correlated with age and creatinine(P <0.05),and the plasma NT-proBNP levels were positively correlated with Cys-C levels and NIHSS score(P <0.05).5.Multivariate logistic regression analysis showed that after adjusting for confounding factors,the plasma NT-proBNP,Cys-C odds ratio(OR),and 95%confidence interval(CI)respectively were 1.022(1.011~1.033)and 6.60(1.279~34.048).Conclusions:1.The increase of plasma NT-proBNP,Cys-C levels is independently related to the occurrence of acute ischemic stroke.2.The plasma NT-proBNP,Cys-C levels in patients with AIS can reflect the severity of the disease to a certain extent.3.The plasma NT-proBNP,Cys-C levels in patients with AIS were positively correlated with age and creatinine.The influence of these factors should be considered when evaluating the levels of NT-proBNP and Cys-C in order to evaluate the disease objectively.