Clinicai Observation Of Nephritis Prescripion In The Treatment Of Chronic Glomerulonephritis With Yang Deficiengcy Of Spleen And Kidney

Purpose:Treating chronic glomerulonephritis with spleen and kidney yang deficiency by Shenyanfang,observe the clinical efficacy and safety of Shenyanfang to provide more reliable and more treatment options for clinical treatment of chronic glomerulonephritis.Study method:74 patients with chronic nephritis who were treated in the outpatient department and inpatient department of the Nephrology Department of Gansu Provincial Hospital of Traditional Chinese Medicine from January 2019 to December 2019 were selected and randomly divided into 37 cases in the control group and 37 cases in the treatment group.Valsartan capsules were given,and the treatment group added Shenyanfang on the basis of the control group;the treatment time of the two groups was the same for 12 weeks.After the clinical observation,the scores of TCM syndromes before and after treatment,quantitative 24-hour urine protein(U-TP / 24h),serum cystatin C(Cys-C),and urinary protein qualitative(PRO)The urine sediment red blood cell(RBC)count was statistically processed and analyzed.Results:(1)Total clinical effectiveness: After the 12-week course of treatment,the treatment group was 88.8% and the control group was 77.7%.After statistical analysis,the treatment effect of the treatment group is considered to be better than that of the control group(P <0.05)(2)Laboratory indicators: 24-hour urine protein quantification,urine protein qualitative,urine red blood cell count,cystatin C and other laboratory indicators were not statistically significant before treatment(P> 0.05),and were comparable,after 12 weeks of drug treatment,the improvement of the above laboratory indicators was significantly improved compared with before treatment.After statistical analysis,it was found that the improvement after treatment was better than before treatment(P <0.05)The improvement was better than the control group(P <0.05).(3)TCM symptom efficacy: The total effective rate in the treatment group was 88.8%,and the total effective rate in the control group was 66.6%.After statistical analysis,the total effective rate in the treatment group was better than that in the control group(P <0.05).Individual TCM indicators: edema,back pain,cold chills,loose stools(diarrhea),cold backpain,pale complexion,lack of food,mental depression,sexual dysfunction(menstrual disorders),two groups of treatment There was no statistical significance before(P> 0.05),which was comparable.After 12 weeks of treatment,the above single TCM symptoms were improved compared with before treatment(P <0.05),including loose stools(diarrhoea)and mental depression After the treatment of sexual dysfunction indicators,the treatment group showed little improvement compared with the control group(P> 0.05),which was not statistically significant.The remaining edema,back pain,cold chills,cold back pain,pale face,and food The improvement of Shao Na Shao and other TCM indicators in the treatment group was better than that in the control group,with statistical significance(P <0.05).During the treatment observation,no adverse events and adverse reactions were found,and no obvious abnormal changes were found in the safety laboratory indicators.