| Objective: Guided by the holistic concept and the theoretical system of syndrome differentiation and treatment of traditional Chinese medicine,this study understood the basic pathogenesis of Diabetic kidney disease(DKD)with deficiency of kidney and blood stasis syndrome fully and explored the clinical efficacy of the Tangshen decoction in the treatment of spleen-kidney qi deficiency and blood stasis syndrome of DKD G2A2-3 stage with the method of "tonifying kidney and promoting blood circulation".The treatment effect can be reflected through the analysis of urinary protein excretion rate,renal function and glucose and lipid metabolism level and the change of traditional Chinese medicine syndrome integral of the experimental group and control group before and after the treatment,so that we can improve the clinical symptoms of the disease,delay the progress of the disease in order to cut off the disease potential,both disease prevention and change.It provides an effective method for preventing and controlling early and middle stage of DKD progression,delaying renal function injury and improving prognosis.Methods: From January 2019 to October 2019,70 patients with spleen-kidney qi deficiency and blood stasis syndrome of DKD G2A2-3 stage who were diagnosed in the outpatient department of nephrology of Affiliated hospital of tianjin academy of traditional Chinese medicine were selected and randomly divided into experimental group and control group,with 35 patients in each group.The control group received basic symptomatic treatment,and the treatment group was treated with the addition and subtraction of the Tangshen decoction based on the treatment of control group.The observation period was 12 weeks.After exfoliation and elimination,62 patients were finally included.Record urinary protein excretion rate,renal function,glucose and lipid metabolism,and other relevant experimental indicators and traditional Chinese medicine syndrome scores of patients in the two groups before and after the treatment.Use SPSS22.0 statistical software to analyze the data and draw conclusions.Results:1.Clinical efficacy: a total of 70 patients were included in this study,7 of whom wereexfoliated and 1 was excluded during the treatment,and the final sample size was 62.After 12 weeks of treatment,15 patients in the experimental group showed significant efficacy,10 were effective,and 8 were ineffective,with a total effective rate of 75.76%.The total effective rate was 51.72% in the control group,2 cases were significantly effective,13 cases were effective,and 14 cases were ineffective.The difference in clinical efficacy between the two groups was statistically significant(P < 0.05).2.Laboratory indicators: After treating for 12 weeks,the differencs between experimental group and control group in the urine protein,serum creatinine(Scr),estimated glomerular filtration rate(e GFR),sugar metabolism,lipid metabolism all have statistical significances(P< 0.05).3.Curative effect of traditional Chinese medicine syndrome: In the experimental group,1case was clinically cured,6 cases were obviously effective,22 cases were effective,4 cases were ineffective,and the total effective rate was 87.88%.In the control group,there were 0cases of clinical recovery,0 cases of obvious effect,13 cases were effective and 16 cases were ineffective,with a total effective rate of 44.83%.The difference in traditional Chinese medicine syndrome efficacy between the two groups was statistically significant(P < 0.05).4.Traditional Chinese medicine syndrome integral:Treating the experimental group and control group after 12 weeks,the differences between the two groups on the traditional Chinese medicine syndrome integral were statistically significant(P < 0.05).5.Safety indicators: There was no statistically significant difference in liver function between the experimental group and the control group before and after treatment(P > 0.05).Conclusion:1.Under the guidance of holistic concept and the theoretical system of syndrome differentiation and treatment of traditional Chinese medicine,use the Tangshen-1created by the method of " tonifying kidney and promoting blood circulation" to treat patients with spleen-kidney qi deficiency and blood stasis syndrome of DKD G2A2-3 stage,the results shown in the experimental group are more significant curative effect,The results showed that the treatment was more effective in the experimental group which can relieve syptoms of spleen-kidney qi deficiency and blood stasis syndrome significantly.2.After treatment,the urine protein excretion rate and glomerular filtration rate in theexperimental group were improved,and the curative effect was better than that in the control group,indicating that the method of invigorating the kidney and activating blood circulation could effectively reduce the urine protein excretion rate and improve the renal function of patients with spleen-kidney qi deficiency and blood stasis syndrome of stage DKD G2A2-3.3.After treatment,the blood glucose and blood lipid levels of both groups were reduced,and the therapeutic effect of the treatment group was better than that of the control group.The kidney-invigorating and blood-activating method could improve the blood glucose and blood lipid metabolism of patients with spleen-kidney qi deficiency syndrome of stage DKD G2A2-3.4.There was no abnormal liver function in the patient before and after treatment,suggesting that the method of tonifying kidney and activating blood circulation is safe and effective in the treatment of spleen-kidney qi deficiency syndrome of stage DKD G2A2-3. |
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