| Objective:1 The clinical efficacy of wenfei tongqiao prescription on children with pulmonary qi deficiency and cold type allergic rhinitis was evaluated by comparing the curative effect of the two groups before and after treatment and the improvement of TCM syndromes.2 By comparing and observing the concentration of secretory Immunoglobulin A(s Ig A)and the concentration of nitric oxide(n NO)in the nasal secretions washing solution before and after treatment in the two groups,the effects of wenfei tongqiao prescription on mucosal immunity and local chronic inflammation in children with lung-qi deficiency and cold allergic rhinitis were comprehensively and objectively evaluated.Methods:The 84 children who met the inclusion criteria were randomly divided into two groups according to the sequence of treatment,namely,the wenfei tongqiao prescription group(experimental group)and the loratadine group(control group).The observation period was 7days.At the end of the treatment period,SPSS21.0 software was used for statistical analysis to compare the changes in the response rate,symptom score and n NO and s Ig A content of children in each group before and after treatment.Meanwhile,the response rate,symptom score and n NO and s Ig A content of children in the two groups were compared.Results:1 Clinical efficacy:1.1 Comparison of overall efficacy:the total effective rate of the experimental group was95%;The total effective rate of the control group was 76.3%.The total effective rate of the two groups before and after treatment and between the two groups after treatment were compared,P<0.05,the difference was statistically significant.It is suggested that after 1 course of treatment,both groups can improve the clinical efficacy and the experimental group is more effective than the control group.1.2 Integral comparison:1.2.1 comparison of total symptom scores:the total score of TCM symptoms in theexperimental group before treatment was 10.63±2.705,and 3.40±1.566 after treatment.Comparison of total symptom scores before and after treatment in the control group showed that Z=-5.388,P < 0.05.Comparison before and after treatment in the two groups,and comparison after treatment between the two groups,P<0.05,the difference was statistically significant,indicating that after one course of treatment,both groups could improve symptoms and the experimental group had a significant effect compared with the control group.1.2.2 Comparison of nasal symptom scores: for the improvement of major clinical symptoms such as sneezing,runny nose,nasal congestion,and nasal itch,the comparison between the experimental group and the control group before and after treatment showed P<0.05,with statistically significant difference.After treatment,P<0.05 showed statistically significant difference between the two groups,indicating that both groups could improve nasal symptoms after 1 course of treatment and the experimental group had a significant effect compared with the control group.2 Nasal exhalation nitric oxide(n NO)concentration(PPB): before and after treatment,n NO concentration in the experimental group was 614.077±82.667 and 410.923±71.592,respectively.The n NO concentration in the control group before and after treatment was631.333±80.853 and 489.333±93.864,respectively.Comparison of n NO before and after treatment in the two groups,comparison of n NO after treatment between the two groups,P<0.05,the difference was statistically significant,suggesting that after a course of treatment,both groups can reduce the concentration of n NO value and the experimental group has a significant effect compared with the control group.3 s Ig A concentration(g/ ml): s Ig A concentration in the experimental group was 13.1±4.26 before treatment and 21.01±2.03 after treatment.The s Ig A concentration in the control group was 13.29±4.16 before treatment and 18.71±1.83 after treatment.SIg A concentration before and after treatment in the two groups was compared,P<0.05,the difference was statistically significant.After treatment,s Ig A concentration between the two groups was compared with P<0.05,indicating a statistically significant difference,suggesting that both groups could improve s Ig A concentration after one course of treatment and the experimental group had a significant effect compared with the control group.4 Adverse reactions:no obvious discomfort was found in the treatment of the two groups of children,and no obvious abnormality was found in the detection of relevant safety indicators before and after treatment,which conforms to the category of medical ethics.Conclusion:1 Both wenfei tongqiao prescription and loratadine tablet can significantly improve the clinical symptoms of children with pulmonary qi deficiency and cold type allergic rhinitis,and the curative effect of wenfei tongqiao prescription is better than loratadine tablet.2 After the two groups of experiments,n NO concentration could be reduced,and the prescription of wenfei tongqiao prescription had better and more significant effect on chronic inflammation of the nose than loratadine.3 Both wenfei tongqiao prescription and loratadine tablet significantly improved the s Ig A concentration of children with pulmonary qi deficiency and cold type allergic rhinitis,and compared with loratadine tablet,wenfei tongqiao prescription could better improve the mucosal immune function of children.4 there was no obvious discomfort reaction in the two groups before and after treatment and during medication,indicating that wenfei tongqiao prescription and loratadine tablets had good clinical efficacy and were safe and reliable in the treatment of children with allergic rhinitis. |
PDF Full Text Request