| Objective To observe the clinical efficacy of wenshenshengbai prescription combined with moxibustion in improving chemotherapeutic bone marrow suppression in breast on the quality of life of chemotherapy patients and other adverse reactions during chemotherapy,such as fatigue,hot flashes,insomnia,pain,poor appetite,nausea,vomiting,diarrhea and constipation,and to monitor the safety.Method Selection of mammary gland of yueyang combine traditional Chinese and western medicine hospital affiliated to Shanghai traditional university using anthracene ring,yew scheme chemotherapy of patients with primary breast cancer 72 study,according to a randomized,controlled method is divided into the controlgroup36 cases treatment group and 36 cases,respectively,to be pure chemother-apy,and kidney and white combined with moxibustion fo-ot three mile,three vaginal intercourse,CV 8,guan yuan,qi hai MDT,treatment time is 4 to 8cycles of chemotherapy,record each cycle of chemotherapy patients(+ /-1 day)7days WBC,neutrophil count and the use of a cycle rh G-CSF dose,observe the difference of two groups of patients with bone marrow inhibition;Middle before chemotherapy,chemotherapy,end of chemotherapy fill in the quality of life of breast cancer patients by(EORCT QLQ C-30),(EORCT QLQ C-BR30),comparing the difference between the control group and treatment group life quality score,the lower the quality of life score,the higher the quality of life,and record chemotherapy lead to fatigue,hot flashes,insomnia,pain,anorexia,nausea,vomiting,diarrhea,constipation and other adverse reactions,carried out in accordance with the CTCAE4.03 grading records,obs-ervation of the treatment group and control group differences in adverse reacti-ons;To evaluate the degree of skin scald,liver and kidney function,blood lipid and other indexes of the patients,and to monitor the safety of moxibusti-on and wenshenshengbai prescription.Result1.In this study,a total of 72 patients with primary breast cancer treated with anthracycline and taxanoid chemotherapy were included.According to the random and control methods,they were divided into the control group(n = 36)and the treatment group(n = 36).All the patients who completed the experiment were women,and the menstrual status,tumor size,clinical staging,pathological type and chemotherapy regimen before enrollment were compared.The final results showed that there was no difference in baseline between the two groups,which was comparable(P>0.05).Comparison of the scores of quality of life before and after treatment: At the end of treatment,the total scores of the breast cancer quality of life scale in the treatment group and the control group were significantly higher than those before chemotherapy(P < 0.05);the total scores of the breast cancer quality of life scale in the treatment group were better than those in the control group(P < 0.05);the overall condition,discomfort symptoms,mood fluctuation and activity of the affected side were improved in the treatment group(P < 0.05).Compared with the control group,the quality of life of breast cancer patients in the two groups improved significantly at the end of chemotherapy(P < 0.05).significantly at the end of chemotherapy(P < 0.05).2.Comparison of bone marrow suppression before and after treatment: at the end point of treatment,leukocyte and neutrophil counts of patients in both groups were decreased by chemotherapy,which was different from that before treatment(P<0.05),and the overall leukocyte and neutrophil counts of the treatment group and the control group were reduced to the same extent,with no statistical significance(P>0.05).With the extension of treatment time,moxibustion combined with medicine in the treatment group can significantly improve the reduction of white blood cell count(P<0.05),while neutrophil count has no effect(P>0.05).Rhg-csf dose in the treatment group was less than that in the control group(P<0.05).Stratified analysis showed that moxibustion combined with moxibustion could significantly improve the reduction of leukocyte count and neutrophil count in patients receiving anthracycline chemotherapy(P<0.05).Leukocyte count decreased in postmenopausal patients(P<0.05),but neutrophil count did not(P>0.05).Moxibustion combined with moxibustion can reduce the dose of rhg-csf for anthracyclines and postmenopausal patients(P<0.05).3.Comparison of quality of life before and after treatment: at the end point of treatment,the total score of the breast cancer quality of life scale in the treatment group and the control group was higher than that before chemotherapy,and the quality of life was decreased(P<0.05).The total score of the breast cancer quality of life scale in the treatment group was lower than that in the control group,and the quality of life was better(P<0.05).The physiological function,emotional status and functional status of the treatment group were significantly improved(P<0.05).At the end of chemotherapy,the scores of breast cancer quality of life in the two groups were lower than those in the middle stage of chemotherapy,and the quality of life was improved(P<0.05).4.Comparison of adverse reactions of patients before and after treatment: at the end point of treatment,both patients in the treatment group and the control group had significant adverse reactions compared with those before chemotherapy(P<0.05);Systemic adverse reactions and gastrointestinal reactions in the treatment group were less than those in the control group(P<0.05).Stratified analysis showed that moxibustion combined with medicine could improve the adverse reactions of taxus and non-menopausal patients(P<0.05).5.Comparison of safety indicators at the end of treatment: at the end of treatment,red blood cells,hemoglobin,platelets,liver function,renal function,blood lipid and other safety indicators in the two groups were all within the normal range,with no statistical significance(P>0.05).No severe skin scald occurred in the treatment group.Conclusion1.Wenshensheng-white prescription combined with moxibustion can improve the reduction of leukocyte and neutrophil counts in breast cancer chemotherapy patients,and reduce the dose of rhg-csf used during chemotherapy,especially for the anthracene ring chemotherapy and postmenopausal patients.2.Wenshenshengbai prescription combined with moxibustion can significantly improve the quality of life of patients with breast cancer chemotherapy,especially the improvement of physiological function,emotional status and functional status.3.Wenshenshengbai prescription combined with moxibustion in the treatment of breast cancer chemotherapy-induced bone marrow suppression has no obvious toxic and side effects,and is safe and reliable. |
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