Study Of Resting-state Brain Function Area In The Acute Thyrotoxic Myopathy

Purpose: To study the changes of resting state networks(RSNs)functional connectivity(FC)changes in the acute thyrotoxic myopathy patients(ATMs)and provide functional imaging basis for the pathophysiology of it.Methods: ATM patients(n=13)were compared with hyperthyroidism controls(n=12)using rs-f MRI.The method of independent component analysis(ICA)was used to obtain the different brain regions of the sensorimotor network(SMN)and the left frontoparietal network(LFPN).At last,pearson correlation analysis was used to investigate the relationships between the value of functional connectivity and clinical indicators.Results: Compared to controls,patients with ATM demonstrated increased functional connection in the cerebellum posterior lobe,cerebellum anterior lobe,right superior temporal gyrus,left post cingulat gyrus,left precuneus and left postcentral gyrus in the SMN,and showed decreased FC in the occipital lobe,frontal lobe,paracentral lobule,inferior parietal lobule and superior parietal lobule(FDR correction,P <0.05).In the LFPN,It showed increased functional connection in the cerebellum posterior lobe,middle temporal gyrus,inferior temporal gyrus and right cingulate gyrus.what is more,it showed decreased functional connection in the frontal lobe,parahippocampa gyrus,inferior temporal gyrus,precentral gyrus and postcentral gyrus(FDR correction,P<0.05).There was no significant correlation among serum levels of FT3,FT4,TGAb,TRAb and TPOAb with different brain area in the ATM.Conclusion: Compared with hyperthyroidism,patients with ATM have abnormal functional connectivity in the SMN and LFPN,which may be associated with the symptom of the acute thyrotoxic bulbar palsy,and it indicates extensive emotional and cognitive dysfunction in ATM patients.