Correlations Between Serum C-peptide,Diabetic Nephropathy,and Carotid Atherosclerosis In Patients With Type Two Diabetics Mellitus

Background: At present,the number of diabetes patients is rising sharply in the world,and its vascular complications are also increasing,which has a huge impact on people’s health.The purpose of this paper is to investigate the relationship between serum C-peptide levels and diabetic nephropathy(DN)and carotid atherosclerosis(CAS)by collecting case data of hospitalized patients with type 2 diabetes mellitus(T2DM).Methods: Collected the hospitalization data of type 2 diabetes mellitus patients who completed the C-peptide release test in the Endocrinology Department of the First Affiliated Hospital of Chongqing Medical University from January 2017 to April 2019,a total of 383 cases.We will discuss the relationship between DN and CAS and divide all T2DM patients into three groups: DN with CAS group,simple DN or simple CAS group,and simple T2DM group to study the variation trend of C-peptide between two kinds of complications.Results: In T2DM patients,DN was statistically associated with CAS(P=0.046).Univariate analysis showed that there were statistical differences in hypertension,diabetic retinopathy(DR),Type of antidiabetic therapy,diabetic autonomic neuropathy(DAN),age,course of diabetes,systolic blood pressure(SBP),fasting C-peptide(FCP),2h-post load C-peptide(2h-CP),and toe-brachial index(TBI)between the DN with CAS group,simple DN or simple CAS group,and the simple T2DM group.The multinomial Logistic regression analysis showed that 2h-CP was independently correlated with DN with CAS in the DN with CAS group and the simple T2DM group(OR=0.806).2h-CP was independently associated with DN with CAS in the DN with CAS group and simple DN or simple CAS group(OR=0.832).Conclusion: In patients with T2DM,DN correlates with CAS.Compared with the simple T2DM group and simple DN or simple CAS group,the FCP and the 2h-CP in the DN with CAS group decreased,and the difference was statistically significant.The multinomial Logistic regression analysis showed that 2h-CP was independently correlated with the DN with CAS group,which suggested that C-peptide might contribute to the occurrence and development of these two complications to some extent.