| Objective: To study the clinical effect of MEBO combined with Niuhuang Zhiqing suppository in promoting wound healing after anal fissure resection,and to observe the effect of the combined medication and dressing change treatment on the clinical manifestations and complications of postoperative wounds in patients with anal fissure.This paper objectively evaluated the clinical efficacy and safety of this therapy,so as to provide more clinical support for the combined therapy in the treatment of wound healing after anal fissure surgery.Methods: according to the inclusion criteria and exclusion criteria,60 patients were diagnosed with anal fissure disease in the anorectal Department of Hubei Provincial Hospital of TCM from December 2020 to September 2021 and all completed anal fissure resections were selected in this study.The patients were randomly divided into two groups: 30 cases in the treatment group（MEBO combined with Niuhuang Zhiqing suppository change）and 30 cases in the control group（Longzhu ointment combined with Niuhuang Zhiqing suppository change）.The two groups of patients were given different drug dressing changes after the operation.The clinical symptoms（wound pain,bloody stool,growth form of wound granulation tissue）,wound healing time and postoperative complications of the two groups of patients on the 2nd,7th,and 15 th days after operation were observed respectively.The quantitative statistics of each observation index were carried out to finally evaluate the clinical treatment effect of each group.Results:（1）After inspection,there was no significant difference in gender,age,course of the disease,stage of anal fissure,and initial wound area between the two groups,therefore the data of the two groups were comparable（P > 0.05）;（2）Degree of wound pain: there was no significant difference in the pain scores between the two groups on the second day after the operation,indicating that the pain scores of the two groups were comparable（P > 0.05）.The pain scores of the treatment group were significantly lower than those of the control group on the 7th and 15 th days after the operation（P < 0.05）.In addition,in the intragroup comparison of the treatment group,the pain scores on the 7th and15 th day after the operation were significantly lower than those on the previous days（P < 0.05）;（3）Hematochezia: there was no significant difference in the score of hematochezia between the treatment group and the control group on the second day after the operation（P > 0.05）.On the 7th and15 th days after the operation,the score of the treatment group was significantly lower than that of the control group（P < 0.05）;（4）Growth of granulation tissue on the wound surface: comparing the data of the two groups on the 7th and 15 th day after the operation,the score of the treatment group was lower than that of the control group,with a significant difference（P <0.05）;（5）Wound healing time: the average healing time of the treatment group was 28.47 ± 1.99 days,while the average healing time of the control group was 32.03 ± 3.32 days.There was a significant difference in wound healing time between the two groups（P < 0.05）;（6）Total effective rate: the curative effects of the treatment group and the control group were compared on the30 th day after the operation.One case in the treatment group was ineffective,and the total effective rate was 96.7%;In the control group,6 cases were ineffective,and the total effective rate was 80%.There was a significant difference between the two groups（P < 0.05）.Conclusion: MEBO combined with Niuhuang Zhiqing suppository dressing change therapy can effectively alleviate the clinical symptoms of postoperative pain and bloody stool in patients with an anal fissure,promote the growth of wound granulation tissue,and shorten the time of wound healing.It is a safe and effective postoperative clinical treatment worthy of promotion. |
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