| ObjectiveObservation of sequential therapy of TCM clinical efficacy in patients with allergic rhinitis,asthma syndrome,immunology,inflammation,lung function,the influence of such indicators for clinical treatment of bronchial asthma to provide a safe,effective,specifications,full of sequential therapy of traditional Chinese medicine,and the high level of Chinese and western medicine treatment of allergic rhinitis,asthma syndrome based on evidence-based medicine。MethodsUse prospective randomized controlled design,will be included in the standard of patients with allergic rhinitis,asthma syndrome,according to the grouping random sampling,the envelope is divided into western medicine group and the maintaining of Chinese and western medicine,western medicine group was given conventional western medicine treatment,maintaining traditional Chinese and western medicine on the basis of western medicine group,according to the grading and staging of patients with sequential therapy of TCM intervention,objective evaluation of two groups of patients before and after treatment clinical curative effect,immunology,inflammation,and lung function changes of the indexes,finally,the test data will be collected using SPSS18.0 software for statistical analysis。Results1.A total of 110 patients were included in this study,including 55 in each of the Chinese and western medicine groups.During the experiment,5 cases fell off in the Chinese and western medicine groups,4 cases were excluded due to non-adherence to the medication,and 1 case was withdrawn due to pharyngeal pain and hoarseness.In the western medicine group,5 cases fell off,and 5 cases were eliminated because they did not adhere to the medication.Finally,100 cases were left,50 cases in each group。2.Baseline situation:35 women and 15 men in the western medicine control group,ranging from 22 years old to 73 years old。There were 34 females and 16 males in the Chinese and western medicine group,with the age ranging from 20 years old to 65 years old。By comparison,there was no statistically significant difference in age and gender between the two groups(P>0.05)。3.ACT score of asthma:There was no statistically significant difference between the two groups before and 4 weeks after treatment(P>0.05)。At 8 weeks and 12 weeks after treatment,the ACT score of the Chinese and western medicine group was higher than that of the western medicine group,and the difference was statistically significant(P<0.05)。In comparison within the group,the differences in ACT scores at different time points between the two groups were statistically significant(P<0.05),both of which were shown as>at 12 weeks after treatment>at 8 weeks after treatment>at 4 weeks before treatment。4.Adult asthma quality of life score(AQLQ):There was no statistically significant difference in the scores of four dimensions(P>0.05)before and after treatment(activity restriction,asthma symptoms,response to stimuli,and confidence in one’s own health)among the groups(P<0.05),while there was statistically significant difference in the scores of four dimensions before and after treatment among the groups(p<0.05)。Psychology dimension score comparison of two groups before treatment there was no statistically significant difference(P>0.05),after treatment,traditional Chinese and western medicine group score higher than western medicine group,the difference was statistically significant(P<0.05),group comparison,Chinese and western medicine treatment group after the score is higher than before the treatment,the difference was statistically significant(P<0.05),there was no statistically significant difference compared before and after the western medicine treatment group(P<0.05)。Comparison of the difference before and after treatment showed that the difference of psychological status before and after treatment in the Chinese and western medicine group was greater than that in the western medicine group,and the difference was statistically significant(P<0.05)。Comparison of the difference between the two groups in other indicators showed no statistical difference(P>0.05)。5.Lung function index results:There was no difference in FEV1,FVC,FEV1/FVC between the two groups before and after treatment(P>0.05),while there was no statistically significant difference in FEV1,FVC,FEV1/FVC between the two groups before and after treatment(P>0.05)。Before and after treatment,there was no statistical difference between the two groups in FEV1,FVC,and FEV1/FVC indexes(P>0.05)。6.Immunological test results:There was no difference in the proportion of Th17 and Treg cells in peripheral blood between the two groups before treatment(P>0.05)。After treatment,the differences in peripheral blood Th17 ratio before and after treatment and between groups were significant(P<0.05),the differences in Treg cell ratio before and after treatment were significant(O<0.05),and there was no difference between groups(P>0.05).Before and after treatment,the difference in the proportion of Th17 cells in peripheral blood of the Chinese and western medicine group was greater than that of the western medicine group,and the difference was statistically significant(P<0.05),while the difference in the proportion of peripheral blood Treg cells between the two groups was not statistically significant(P>0.05)。7.Inflammatory test results:There was no difference in serum IgE and TNF-α levels between the two groups before treatment(P>0.05)。After treatment,the difference of serum TNF-α level in each group before and after treatment and between groups was significant(P<0.05),while the difference of serum IgE level in each group before and after treatment was significant(P<0.05),and there was no difference between groups(P>0.05)。Before and after treatment,the difference of serum TNF-α level in the Chinese and western medicine group was greater than that in the western medicine group,and the difference was statistically significant(P<0.05),while the difference of serum IgE level between the two groups was not statistically significant(P>0.05)。8.Adverse reactions happen:The course of treatment,there were 2 cases of adverse events,including integrated traditional Chinese and western medicine treatment group 1 case,western medicine control group 1 case,adverse events for patients using inhalant hoarse and oral mucosa after white spot is unwell,after treatment for strengthening gargle and inhalant technology,a week with the disease,patients’symptoms。Conclusion1.Sequential therapy of traditional Chinese medicine can effectively relieve the clinical uncomfortable symptoms of asthma patients and improve the quality of life;2.Sequential therapy of traditional Chinese medicine can reduce the serum level of TNF-α in patients with allergic rhinitis-asthma syndrome and reduce the inflammatory response;3.Sequential Chinese medicine therapy can reduce the proportion of Th17 cells in peripheral blood of patients with allergic rhinitis and asthma syndrome by regulating Th17/Treg balance,and reduce airway inflammation and airway hyperreactivity;4.Further clinical studies are needed to determine whether sequential TCM therapy can improve lung function and reduce serum IgE expression in patients with asthma;In general,in the treatment of patients with allergic rhinitis and asthma syndrome,the sequential therapy of traditional Chinese medicine can regulate the Th17/Treg balance and reduce the serum TNF-α level to reduce the airway inflammatory response and improve the clinical symptoms,so as to achieve the purpose of treating the disease.The two-month drug intervention found the superiority of the treatment group of integrated traditional Chinese and western medicine,which provided a new perspective and perspective for the further development of related large-sample prospective research。... |
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