| Objective: In this project,the tutor’s self-prepared Ningchang No.2 prescription is used to treat patients with diarrhea-type irritable bowel syndrome with spleen deficiency and qi stagnation syndrome,to evaluate the clinical efficacy and safety of the prescription,and to provide data support for the preparation of in-hospital Chinese medicine preparations.Methods:According to diagnostic criteria,70 patients with IBS-D spleen-deficiency qi stagnation and dampness obstruction syndrome in the Affiliated Hospital of Shanxi University of Traditional Chinese Medicine were collected and divided into a treatment group(35 cases of Ningchang Ⅱ Formula)and a control group(35 cases of Buzhong Yiqi Pills).Take 4 weeks as a course of treatment,and each group of patients will have weekly follow-up visits,and the changes will be recorded after the course of treatment.Organize and enter the obtained data.The SPSS25.0 statistical software is used to obtain the research results according to different data and corresponding statistical methods.Results:(1)After the treatment period,the effective rates of TCM syndromes in the treatment group and the control group were 94.29% and 71.43%,respectively,and the effective rates of the main symptoms were 91.43% and 74.28%;the above effective rates were all analyzed by Chi-square.P<0.05;After treatment,the curative effect was tested by rank sum test,P<0.05,the difference was statistically significant(P<0.05).(2)The total scores of TCM syndromes and main symptoms of the two groups of patients before and after treatment were compared within the group,P<0.01,the difference was statistically significant;after treatment,the total scores of TCM syndromes and main symptoms of the two groups of patients were Differences were compared between groups,using rank sum test,P<0.05,and the differences were statistically significant.(3)Single symptom comparison in traditional Chinese medicine: The rank sum test was used to compare between groups after treatment,and the difference was statistically significant(P<0.05).Among them,in the five groups of improving diarrhea,abdominal pain,bowel,fullness of the abdomen,and loss of appetite,P<0.01,indicating a significant difference;in terms of improving the symptoms of fatigue episodes,the result of the rank sum test was P<0.05,The difference was statistically significant;in the treatment of four single symptoms of fatigue,fatigue,belching,and prolapse,P>0.05,the difference was not statistically significant.Main symptom scores: The rank sum test of two related samples was used to compare within the group,P<0.05,and the difference was statistically significant.After treatment,the difference in the main symptom scores of the two groups of patients was compared between the groups.<0.05,indicating that the difference is statistically significant.(4)The two groups of patients were subjected to the three major routine tests of hematuria and stool,liver function,renal function tests,and electrocardiogram before and after treatment.All recorded indicators did not indicate abnormal changes,and there was no drug allergy and drug allergy during the treatment Other symptoms of discomfort.It can be seen that Ningchang Ⅱ prescription is safe and reliable in treating this disease.Conclusion: Ningchang Ⅱ prescription has achieved good therapeutic effects in terms of single symptoms and main symptoms of Chinese medicine,especially in improving diarrhea,abdominal pain,bowel,fullness of the abdomen,and loss of appetite.It is far superior to Buzhong Yiqi Pills.,And there is no significant difference in improving the four individual symptoms of fatigue,fatigue,lazy speech,belching,and rectal prolapse.Ningchang Ⅱ prescription is more effective in treating this disease than Buzhong Yiqi Pills.Based on the above research results,the Ningchang Ⅱ prescription has a significant clinical effect in the treatment of this disease,and has a high safety factor,which is worthy of popularization and application by clinicians. |
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