The Clinical Study Of Self-made Jieyu Yihao Prescription Combined With TIP In Treatment Of Depression Of Ganyupixv Type

Objective:To explore the effect of Jieyu Yihao prescription combined with 1 Low resistance state thought introduction therapy on improving the clinical symptoms of patients with mild to moderate depression(ganyupixv type),the therapeutic efficacy and drug safety were analyzed.Methods:A total of 112 patients with mild to moderate depression who were admitted to the Seventh people’s Hospital in Wenzhou from October 2017 to September 2019 were randomly divided into control group and Observation Group.There were 57 cases in control group and 55 cases in observation group.The patients in the control group were treated with Low resistance state thought introduction therapy(TIP)combined with western medicine basic antidepressant drugs,while the patients in the observation group were treated with Jieyu Yihao prescription on the basis of TIP combined with medical basic antidepressant drugs,the two groups were treated for 8 weeks.patients’s liver and renal function,Hamilton depression scale(HAMD),Hamilton Anxiety Rating Scale scale(HAMA),self-esteem scale(SES)and General self-esteem scale(GSES)were assessed before treatment,4 weeks after treatment and 8 weeks after treatment,respectively.The effective rate of anxiety and the incidence of adverse events during treatment are analyzed.Result:1.Before treatment,there were no significant differences in serum alanine transaminase(ALT),aspartate transaminase(AST)and creatinine(CR)between the two groups(p<0.05),there were no significant changes in ALT,AST and CR levels in both groups at 4 and 8 weeks after treatment(p>0.05).2.There was no significant difference in HAMD depression score between the observation group and the control group before treatment(p>0.05).HAMD depression score of the two groups decreased significantly after 4 weeks and 8 weeks treatment(p<0.05),HAMD depression score of the two groups had no significant difference(p<0.05),but HAMD depression score of the observation group was significantly lower than that of the control group(13.67±1.69 vs.15.86±1.84,p=0.007)after 8 weeks of treatment.Similarly,there was no significant difference in HAMA scores between the two groups before treatment(p>0.05).Compared with that before treatment,HAMA scores decreased significantly after 4 and 8 weeks of treatment in both groups(both p<0.001).And at 4th and 8th week,HAMA scores in the observation group were significantly lower than that in the control group(both p<0.05).3.Before treatment,there was no significant difference in SES self-esteem scale and GSES self-efficacy between the Observation Group and the control group(both p<0.05),after 8 weeks of treatment,SES and GSES of both groups were significantly improved(both p<0.05),and at the 8th week of treatment,both SES and GSES of the observation group were better than those of the control group(both p<0.05).4.During the treatment period,there were no significant differences in the adverse reactions of nausea,dry mouth,consTIPation,headache,sweating,fatigue and palpitation(all p>0.05),18 cases(31.6%)in the control group and 8 cases(14.5%)in the Observation Group,there was significant difference between the two groups(p=0.033).Conclusion:Self-made Jieyu Yihao prescription combined with western medicine basic treatment and TIP Chinese medicine psychotherapy can further improve anxiety and depression of mild and moderate depression(liver depression and spleen deficiency type),enhance self-esteem and general self-efficacy level,it has high drug safety and is worth using in the treatment of mild to moderate depression.