Relationship Between 24h Urinary Sodium-potassium Ratio And Central Arterial Pressure In Patients With Essential Hypertension

Objective To investigate the relationship between 24 h urinary sodium-potassium ratio and central arterial pressure in patients with essential hypertension.Methods from January 2016 to December 2019,1053 patients with essential hypertension were selected from the Department of hypertension,the hypertension Department of the heart Center of our hospital.24 h urinary sodium-potassium ratio was measured.According to the quartile method of 24-hour urinary sodium potassium ratio,the patients were divided into three groups: T1(24h urinary sodium potassium ratio ≤ 3.27,male 169,female 180),T2(24-hour urinary sodium potassium ratio 3.27-4.89,male 175,female 181),T3(24-hour urinary sodium potassium ratio ≥ 4.89,male 189,female 159).The general clinical data of the patients were retrospectively studied,and the urine electrolytes,central arterial pressure and other related indicators were collected.Objective to investigate the correlation between 24 hour urinary sodium-potassium ratio and central arterial pressure and its influencing factors.Results There were no significant differences in gender,BMI,admission pulse pressure,heart rate,fasting blood glucose,triglycerides,total cholesterol,creatinine,urea nitrogen,serum sodium,24 h urine volume,24 h urine protein quantity,24 h urine microalbumin and CDP among 3 groups(P > 0.05).There were statistically significant differences in age,admission systolic blood pressure,admission diastolic blood pressure,high density lipoprotein cholesterol,low density lipoprotein cholesterol,serum potassium,24 h urinary sodium,24 h urinary potassium,CSP,CPP and AIX75(P <0.05).Pearson correlation analysis showed that 24 h urinary sodium-potassium ratio was positively correlated with CSP,CPP and AIX75 [r=0.227,r=0.229,r= 0.859].Multivariate logistic regression analysis showed that age,24 h urinary sodium and 24 h urinary sodium potassium ratio were the risk factors for CSP elevation.[OR(95%CI)were 1.010(1.001 ～1.110),1.031(1.021 ～ 1.041),1.074(1.017 ～ 1.133)].Elevated urinary sodium at 24 hours was a risk factor for elevated CPP.[OR(95%CI)1.017(1.010 ～ 1.024)].After adjustment for age,sex,and heart rate,increased 24 h urinary sodium and 24 h urinary sodium to potassium ratio were found to be risk factors for increased AIX75.[OR(95%CI)were1.010(1.003 ～ 1.018);1.664(1.508 ～ 1.837);0.914(0.896 ～ 0.932)].Elevated urinary potassium at 24 hours was a protective factor for CSP,CPP and AIX75 [OR(95%CI)=0.885(0.867-0.904),0.934(0.921-0.947)and 0.914(0.896-0.932),respectively].Conclusion In patients with essential hypertension,the increase of 24 h sodium-potassium ratio was positively correlated with the increase of CSP,CPP and AIX75.The increase of24 h sodium-potassium ratio was an independent risk factor for the increase of CSP and AIX75.Compared with CSP,the increase of 24 h sodium-potassium ratio was more strongly correlated with AIX75.