| Objective:To explore the relationship between serum T-cell immunoglobulin and mucin domain 1(Tim-1)levels and lung cancer,clinical parameters and different pathological types,and to find a potential marker for the diagnosis of lung cancer.Methods: A total of 100 patients diagnosed with primary lung cancer and 40 healthy subjects in the Physical Examination Center of the First Affiliated Hospital of Dali University from January 2020 to December 2020 were collected.3ml of venous blood was collected for each patient,and the clinical data of the patients were collected.Serum TIM-1 concentration of the samples was determined by ELISA kit.Serum TIM-1concentrations in the two groups of people were compared,and serum TIM-1concentrations in lung cancer patients were compared with relevant clinical parameters and different pathological types,so as to determine the relationship between serum TIM-1 concentration changes and lung cancer,clinical parameters and different pathological types.The sensitivity and specificity of serum Tim-1 in lung cancer were further evaluated by ROC curve analysis.Results: A total of 100 lung cancer patients were collected,aged 42-89 years old,with an average of(64.25±8.44)years old.There were 40 healthy subjects,aged 52-87 years,with an average of(69.20±10.56)years.(1)Among the basic characteristics of the study population,there were differences in the distribution of BMI and TC(P<0.05),but no differences in the distribution of age and TG(P>0.05).(2)In comparison of serum Tim-1 levels in lung cancer group and control group,serum Tim-1 levels in lung cancer group(median 182.2pg /ml,25%-75% : 136.8-297.2pg /ml)were higher than those in control group(median 127.1pg /ml,25%-75% :70.6-188.9pg /ml),and there was significant difference between the two groups(P<0.0001).(3)The ROC curve analysis results of serum Tim-1 in the diagnosis of lung cancer showed that the area under the ROC curve was 0.709(P < 0.001),the cut-off value on the ROC curve was 115.4pg/ml,and the sensitivity was 85.0% and the specificity was 47.5%.(4)Serum TIM-1concentration and risk analysis of related clinical parameters in the lung cancer group and the control group showed that TIM-1 concentration was associated with the risk of lung cancer(OR,1.010;95% CI,1.004-1.016),BMI and risk of lung cancer(OR,0.637;95% CI,0.519-0.783),TC and risk of lung cancer(OR,0.479,95% CI,0.294-0.779).(5)There was significant difference between serum TIM-1 concentration and lymph node metastasis in lung cancer patients(P<0.05).There was no significant difference in age,smoking status,tumor size and TNM stage(P>0.05).(6)There was no significant difference in serum TIM-1 level between patients with lung cancer and Ca2+and common tumor markers(P>0.05).(7)The correlation between serum TIM-1 level and pathological types of lung cancer patients was significantly higher in squamous cell carcinoma(median 182.9pg/ml,25%-75% : 144.6-307.9pg/ml)and adenocarcinoma(median 177.5pg/ml,25%-75% :101.0-270.9pg/ml),small cell carcinoma(median203.6pg/ml,25%-75% : 136.5-283.0pg/ml),and there was no difference in serum Tim-1concentration among the three groups(P>0.05).Conclusion:1.Serum Tim-1 can be used as a tumor marker and sensitivity index for early detection of lung tumors.2.Serum Tim-1 can be used as a monitoring index for lymph node meta stasis of lung cancer. |
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