Clinical Observation Of Tongnao Yin On Treating Acute Cerebral Infarction With Obstructive Sleep Apnea Hypopnea Syndrome

Objective To investigate the effects of Tongnaoyin treatment and explore its mechanism by observing the changes of TCM syndrome score,neurological function defect degree,disability degree,quality of daily life,AHI and blood oxygen saturation in patients with acute cerebral infarction with OSAHS before and after treatment.Metords Patients with acute cerebral infarction with OSAHS who were hospitalized in the encephalopathy center of Jiangsu Hospital of Traditional Chinese Medicine on September 1,2020 and January 31,2021 and who met the standards of sodium discharge were included.After admission,the patients were randomly divided into control group and experimental group according to the treatment method.A total of 40 cases were included,and 20 cases were in the control group and the observation group,respectively.The control group was given conventional western medicine treatment,and the observation group was given Tongnaoyin on the basis of the control group.The treatment course was 28 days.NIHSS score,MRS score,Barthel index,AHI and the lowest SPO before and after treatment were observed in 2 groups2,TCM syndrome scores and clinical efficacy.SPSS statistical software was used to analyze the data to evaluate whether Tongnaoyin could improve the early neurological function deficit,sleep apnea index,blood oxygen saturation and safety of patients with acute cerebral infarction complicated with OSAHS.Results1.NIHSS score:After treatment,the NIHSS score in both groups was significantly decreased with high statistical significance(P<0.01);There was no statistically significant difference in NIHSS scores between the observation group and the control group after treatment(P>0.05),but the decrease of points in the observation group was significantly greater than that in the control group.2.MRS score:After treatment,the MRS score in both groups was significantly decreased with statistical significance(P<0.01);There was no statistically significant difference in the MRS scores between the observation group and the control group after treatment(P>0.05).3.Barthel index:After treatment,Barthel index in both groups was significantly improved with statistical significance(P<0.01);There was no significant statistical difference in Barthel index between the observation group and the control group after treatment(P>0.05).4.AHI:After treatment,AHI in both groups was significantly decreased with statistical significance(P<0.01);The comparison of Barthel index between the observation group and the control group after treatment showed no significant statistical difference(P>0.05),but the decrease degree of AHI in the observation group was significantly higher than that in the control group.5.Minimum SPO2:The lowest SPO before and after treatment was compared between the two groups2,the lowest SPO was found in both groups after treatment2Were significantly increased and had significant statistical significance(P<0.01);The observation group and control group had the lowest SPO after treatment2There was no statistically significant difference(P>0.05),but the observation group had the lowest SPO2The degree of elevation was significantly higher than that of the control group.6.TCM syndrome scores:After treatment,TCM syndrome scores in both groups were significantly decreased with statistical significance(P<0.01);The comparison of TCM syndrome scores between the observation group and the control group after treatment showed no significant statistical difference(P>0.05),but the decline degree of the observation group was higher than that of the control group.7.Effectiveness:The overall effective rate of the observation group was better than that of the control group,with statistical difference(P<0.05).ConclusionTongnaoyin combined treatment can reduce the neurological deficit score and apnea hypopnea index in patients with acute cerebral infarction with OSAHS,and improve the minimum blood oxygen saturation.The efficacy is batter than that of control group,and there is no obvious adverse reactions.