Clinical Observation Of Tengqi Tongbi Decoction In The Prevention And Treatment Of Peripheral Neurotoxicity Of Oxaliplatin

Objective: To observe the clinical efficacy of Tengqi Tongbi Recipe in the prevention and treatment of oxaliplatin peripheral neurotoxicity.So as to provide certain theoretical and clinical support for traditional Chinese medicine to prevent and treat oxaliplatin peripheral neurotoxicity.Method: Sixty patients with gastric cancer or colorectal cancer who met the inclusion criteria were randomly divided into control group and observation group,with 30 cases in each group.All patients were treated with chemotherapy containing oxaliplatin.The control group instructed patients to avoid contact with cold water during the treatment period of oxaliplatin and within 24-48 hours after treatment,wear gloves and socks to keep warm for about 1 week,avoid contact with cold objects,and avoid eating raw and cold food.On this basis,the observation group was given external washing with Tengqi Tongbi Fang from the first cycle of chemotherapy,7 days as a course of treatment,and 3 cycles in a row.After each cycle,the two groups were scored on the FACT/GOG-Ntx scale.After the third cycle,the oxaliplatin-specific neurotoxicity Levi classification was performed,and the safety of Tengqi Tongbi Prescription was observed and evaluated.Results: 1.There was no statistical difference between the control group and the observation group in the average cumulative measurement of oxaliplatin(P>0.05).2.There was no significant difference in FACT/GOG-Ntx scale scores between the two groups after the end of the first cycle(P>0.05).After the end of the second and third cycles,the scores of the observation group were lower than those of the control group(P<0.05).3.After the third cycle,the incidence of peripheral neurotoxicity in the observation group was lower than that in the control group(P<0.05).4.After the third cycle,the Levi classification of oxaliplatin-specific neurotoxicity in the observation group was better than that in the control group(P<0.05).5.Safety evaluation: No adverse reactions occurred in the two groups during the observation.Conclusion:Tengqi Tongbi Recipe can reduce the incidence and severity of oxaliplatin peripheral neurotoxicity.The method of replenishing qi,activating blood,warming yang and dredging collaterals with Tengqi Tongbi Recipe as the main prescription has certain curative effect in the prevention and treatment of oxaliplatin-induced peripheral neurotoxicity,and has high safety.