A Study On The Curative Effect Of Parents With Attention Deficit Hyperactivity Disorder In Childhood On The Treatment Of Children With The Same Disease

【Objective】A prospective study was conducted based on children with attention deficit hyperactivity disorder(ADHD)aged 6～16 years old.They were divided into two groups according to whether their parents had ADHD in childhood.The difference of curative effect between the two groups was compared and discussed to explore whether the parents’ ADHD in childhood would affect the curative effect of ADHD children,so as to provide new ideas for the treatment of ADHD in the future.【Methods】126 children with ADHD,from the outpatient department of child mental health research center of Brain Hospital Affiliated to Nanjing Medical University and the psychological outpatient department of Nanjing Children’s Hospital,were enrolled by convenient sampling method from December 2018 to December 2019,including 42 in the experimental group and 84 in the control group.All the enrolled parents filled in the general situation questionnaire,cooperate with the researcher to answer the relevant items of the Chinese version of Swan Nolan and Pelham version Ⅳscale-parent form(SNAP-Ⅳ),according to the children’s symptoms and the review of their childhood.The children take integrated visual and audit continuous performance test(IVA-CPT)and Wechsler or raven intelligence test.The children were grouped according to the score of SNAP-IV self rating scale for parents.All the children were treated with single drug of atomoxetine hydrochloride for 8 weeks,followed up to the end of the 8th week,and returned to the outpatient department every two weeks.The patients were reexamined with IVA-CPT and reassessed with SNAP-Ⅳ.Independent sample t-test and Chi-square test was used to compare the comparability between the experimental group and the control group.The curative effects of the experimental group and the control group were compared by the methods of generalized estimation equation,repeated measurement analysis of variance,independent sample t-test and rank sum test.【Results】(1)There was no significant difference in sex,age,IQ,family education style,annual family income,parents’ education background,occupation and Snap-Ⅳ and IVA-CPT baseline scores before administration between the experimental group and the control group(P>0.05);(2)After 8 weeks of drug treatment,the scores of each factor of SNAP-Ⅳincluded attention factor,hyperactivity/impulse factor,oppositional defiance factor and total score and he scores of IVA-CPT included comprehensive control quotient,comprehensive attention quotient,visual control quotient,auditory control quotient,visual attention quotient and auditory attention quotient were significantly different(P<0.05).And the curative effect was better and better with time(P<0.05);(3)After 8 weeks of drug treatment,the improvement of attention factor,hyperactivity/impulse factor,oppositional defiant factor and total score in the control group were more significant than those in the experimental group(P<0.05);(4)According to the results of simple effect analysis,when time effect was fixed,the total score of SNAP-Ⅳand the score of oppositional defiant factors between the two groups were both different at the end of the second week(P<0.05),the scores of hyperactivity/impulse factor and attention factor were different at the end of the fourth week and the sixth week respectively(P<0.05).When group effect was fixed,the score of oppositional defiant factors in the experimental group was different from that before the treatment from the end of fourth week(P<0.05).The other factors in the two groups were all different from those before treatment from the second week(P<0.05);(5)The results of generalized estimation equation showed that there were group differences between visual attention quotient and auditory control quotient(P<0.05),there was no group difference in other quotients(P>0.05).There was no group difference in all quotients of the results of repeated measurement analysis of variance(P>0.05);(6)According to the deduction rate,the difference between the experimental group and the control group was found in the second,fourth and eighth week(P<0.05),and the effect of the control group was better.【Conclusion】(1)Whether parents have ADHD symptoms in childhood or not,all the children can achieve curative effect after drug treatment,and the effect is getting better and better over time.(2)When parents have ADHD symptoms in childhood,the drug effect of their ADHD children will be worse than those ADHD children whose parents have no ADHD symptoms in childhood.(3)When parents have ADHD symptoms in childhood,the effective time of their ADHD children after drug treatment will be later than those ADHD children whose parents have no ADHD symptoms in childhood.