| Objective:Observe the clinical effect of this prescription on focal scleroderma of phlegm blocking blood stasis type by oral administration of Jiawei Mahuang Fuzi Xixin Decoction.Methods:Random number tables were used to generate random seed numbers and grouping numbers for 60 patients who met the inclusion criteria.There were 30 cases in the observation group and 30 cases in the control group.All patients in the control group were given colchicine orally,and the observation group was treated with Jiawei Mahuang Fuzi Xixin Decoction.The course of treatment in both groups was 8 weeks.Before starting treatment,patients in both groups were given scores of TCM syndromes and C response for 8weeks.Protein,dynamic erythrocyte sedimentation rate,modified Rodnan skin scoring(MRSS),visual analogue scoring(VAS),blood routine,urine routine,stool routine,liver function,kidney function,electrocardiogram,after the end of the experiment and before the treatment,comparative analysis,Observe its index changes and adverse reactions,and use SPSS 26.0 software for data statistical analysis.Results:(1)In this research,a total of 30 cases in the observation group were collected,2cases were dropped,28 cases were in fact,30 cases in the control group,3 cases were dropped,and 27 cases were accepted.(2)Skin mobility:After 8 weeks of treatment,the overall scores of MRSS and VAS in the observation group were significantly lower than those before treatment,and were better than those in the control group(P<0.05).(3)Disease inflammation indicators:After 8 weeks of treatment,the C-reactive protein and dynamic erythrocyte sedimentation rate values of the observation group were significantly lower than those before the treatment,which was better than the control group(P<0.05).(4)TCM syndrome score: After 8 weeks of treatment,the individual TCM syndrome scores of the observation group and the control group decreased,and the difference in skin hardness and finger(toe)pain was statistically significant(P<0.05),but there was a difference in joint pain No statistical significance(P>0.05).The total scores of TCM syndromes of the observation group and the control group were lower than before treatment(P<0.05),and the total scores of TCM syndromes of the observation group were lower than those of the control group,and the difference was statistically significant Academic significance(P<0.05).(5)The curative effect of traditional Chinese medicine symptoms: after 8 weeks of treatment,4 cases were ineffective in the observation group,9 cases were effective,13 cases were markedly effective,and 2 cases were cured clinically,with a total effective rate of 85.71%;in the control group,10 cases were ineffective,16 cases were effective,and 1 case was markedly effective.0 cases were clinically cured,and the total effective rate was 62.96%.After comparative treatment,the observation group was better than the control group,and the difference was statistically significant(P<0.05).(6)Adverse reactions: There were no statistically significant differences in white blood cells,alanine aminotransferase,aspartate aminotransferase,creatinine,and electrocardiogram before and after treatment between the two groups(P>0.05).The adverse reaction rate of the observation group was 3.57%,and the adverse reaction rate of the control group was 14.81%.The adverse reaction rate of Jiawei Mahuang Fuzi Xixin Decoction in the treatment of focal scleroderma was lower than that of colchicine alone.There was no statistical difference between the groups(P>0.05).Conclusions:Modified Mahuang Fuzi Xixin Decoction in the treatment of focal scleroderma with phlegm obstruction and blood stasis type can significantly improve ESR,CRP,MRSS,VAS,and TCM syndrome scores,indicating that Jiawei Mahuang Fuzi Xixin Decoction treats phlegm obstruction and blood stasis type focal scleroderma Dermatosis has a good curative effect,the adverse reactions did not increase compared with the control group,and no serious adverse reactions were seen. |
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