Clinical Observation On Treating Premature Ovarian Insufficiency Of Kidney Yang Deficiency Type By Moxibustion At Shu Mu Points Separated By Aconite Cake

Objective:Objective To observe the clinical efficacy of moxibustion at Shenshu and Jingmen points separated by radix aconiti carmichaeli cake and oral administration of fenmatong in the treatment of premature ovarian insufficiency of kidney yang deficiency type,and to compare the improvement of TCM symptoms and serum sex hormones between them,so as to provide a new reference for the clinical treatment of premature ovarian insufficiency of kidney yang deficiency type.Methods:66 patients with premature ovarian insufficiency of kidney yang deficiency type were randomly divided into experimental group and control group,33 cases in each group.Experimental group: Shenshu(double),Jingmen(double)separated aconite cake moxibustion treatment.The intervention time of moxibustion was between menstrual period and premenstrual period(equivalent to ovulation and luteal phase),once a day,14 times a course of treatment,a total of 3 menstrual cycles.Control group: take fenmotong from the first day of menstrual cycle,one tablet per day,every 28 days as a course of treatment,taking three menstrual cycles continuously.The TCM symptom scores before and after treatment and 3months after treatment were collected,and the levels of serum follicle stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)before and after treatment were recorded.All data were analyzed by spss24.0 statistical software.Result:1.Comparison of TCM symptom scores after treatment: within the group,the TCM symptom scores of the two groups were lower than before treatment(P<0.05);between the groups,the experimental group was better than the control group in improving TCM symptoms.2.Comparison of TCM symptom scores in follow-up period: compared with before treatment,TCM symptom scores in two groups during follow-up period were lower than before treatment(P<0.05);compared with after treatment,there was no significant difference in experimental group(P>0.05);TCM symptom scores in control group during follow-up period were higher than after treatment(P<0.05);TCM symptom scores in experimental group were lower than those in control group(P<0.05);TCM symptom scores in experimental group were higher than those in control group(P<0.05);TCM symptom scores in experimental group were lower than those in control group(P<0.05),The long-term effect of the treatment group was better than that of the control group.3.Comparison of serum FSH,LH and E2 after treatment: within the group,FSH and LH in the two groups were lower than before treatment,while E2 was higher than before treatment(P<0.05).There was no significant difference between the two groups(P>0.05);both groups could improve the hormone level,and the curative effect was similar.4.Comparison of clinical efficacy: the total effective rate of the experimental group was87.10%,and that of the control group was 80.65%,with statistical significance(P<0.05).Conclusion:1.Both Shu Mu Acupoint Moxibustion with Aconite cake and oral fenmatong can improve the clinical symptoms of patients with premature ovarian insufficiency of kidney yang deficiency type,and Shu Mu Acupoint Moxibustion with Aconite cake is more effective.2.Both moxibustion with Aconite cake separated by Shu and Mu points and oral administration of fenmatong can reduce FSH and LH,and increase E2 in patients with premature ovarian insufficiency of kidney yang deficiency type.3.Moxibustion with Shu and Mu points separated by aconite cake has definite clinical efficacy in treating premature ovarian insufficiency of kidney yang deficiency type,and in terms of long-term efficacy,moxibustion with Shu and Mu points separated by aconite cake is better than that with femotong.