Clinical Study Of Modified Six-serenity Decoction In The Treatment Of AECOPD Patients With Phlegm-dampness Accumulatation In Lung Syndrome

Objective:To evaluate the clinical efficacy of modified six-serenity decoction in reducing the level of inflammation,improving the symptoms and the level of lung function in patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）,and to understand the internal connection between patients with AECOPD of phlegm-dampness accumulatation in lung syndrome and the onset time,so as to provide clinical research evidence for the treatment of COPD with traditional Chinese medicine.Methods:In this study,50 patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）with phlegm-dampness accumulation in the lung syndr ome who met the criteria were selected and randomly divided into study group and control group.The control group was given routine treatment,and the study group was given modified six-serenity decoction on the basis of the control group.Both groups were treated for 14 days.From before the treatment intervention to the end of the treat ment course,the two groups dynamically observed the curative effect index,symptoma tic index,biological index,lung function index collected at admission and 14th day.Objective to study the relationship between seasons and causes of acute exacerbation of COPD by analyzing data.Result:1.Comprehensive efficacy comparison:The total effective rates of the study group and the control group were 100%and 91.3%,respectively.The comprehensive curative effect of the study group was higher than that of the control group.2.Comparison of symptomatic indicators:After treatment,the TCM syndrome scores of the two groups were significantly lower than before,and after treatment,the TCM syndrome scores of the study group were lower than those of the control group.After treatment,the CAT scores of the two groups were significantly improved compared to before,and the difference of the CAT scores of the study group before and after treatment was higher than that of the control group.There was no statistical difference in the scores of TCM expectoration symptom control between the two groups.3.Comparison of biological indexes:There was no statistical difference in the white blood cell counts between and within the two groups before and after treatment.After treatment,the PCT results of patients in two groups were improved compared to before treatment,but there was no statistical difference in the comparison of the PCT results between the two groups of patients.After treatment,the NLR value of patients in the study group improved compared with before treatment,while the control group had no statistical difference compared with before.The NLR difference of the patients in the study group before and after tre atment was higher than that of the control group.After treatment,the CRP values of the two groups were significantly improved compared to before,and the CRP differenc e of the patients in the study group before and after treatment was higher than thatof the control group.After treatment,there was no statistical difference in the comparison of the Pa O₂values of the two groups of patients between and within the group before and after treatment.4.Comparison of lung function indexes:After treatment,the FEV1 values of the two groups were significantly improved compared to before,but the remaining FEV1 and FEV1/FVC values of the two groups of patients were not statistically different betwe en and within the two groups before and after treatment.5.There are 14 cases of COPD patients with phlegm-dampness accumulation in the lung syndrome occurred in spring,16 cases in summer,11 cases in autumn,and 5cases in winter.The cause of the disease is related to imbalance of cold and heat in 19 cases,and sudden changes in weather in 16 cases.Other causes were few or difficult to clarify.6.The safety indexes of urine and feces routine,liver and kidney function,ECG and so on were included in this study.No damage caused by this study was found,which confirmed the safety of modified six-serenity decoction in clinical application.Conclusion:1.Compared with routine western medicine treatment,combined with traditional Chi nese medicine modified six-serenity decoction in the treatment of AECOPD patients w ith phlegm-dampness accumulatation in lung syndrome,it can enhance the efficacy,red uce inflammation,improve clinical symptoms,improve quality of life,and have high safet y and no toxic side effects.2.The onset time of patients with acute exacerbation of chronic obstructive pulmo nary disease（COPD）of phlegm-dampness accumulation in lung syndrome is probably in spring and summer.The triggers of the onset are related to factors such as sudden changes in weather,cold and heat imbalance,and can be targeted for prevention.