Clinical Observation Of Sijunzi Decoction Combined With Baohe Pill To Treat The Postprandial Discomfort Syndrome Of Spleen Deficiency And Qi Stagnation Syndrome

Objective: Using Sijunzi Decoction combined with Baohe Pill to treat the Postprandial Discomfort Syndrome(PDS)with spleen deficiency and qi stagnation and compared with mosapride citrate dispersible tablets.Observing and comparing the improvement of patients’ discomfort symptoms,quality of life,anxiety and depression,and the recurrence rate after stopping the drug.Discussing the clinical effect of Sijunzi Decoction combined with Baohe Pill in treating PDS patients with spleen deficiency and qi stagnation syndrome,and providing the basis for its clinical application.Methods: According to the inclusion and exclusion criteria,70 cases of PDS patients with spleen deficiency and qi stagnation were in this clinical study.Include cases were divided into treatment group and control group with 35 cases each according to the random number table method.The treatment group was treated with Sijunzi Decoction combined with Baohe Pill,Chinese medicine formula granules 200 ml each time,twice a day,and take it with boiling water 30 minutes before meals.The control group was treated with mosapride citrate dispersive tablets,western medicine tablets 5mg each time,3 times a day,orally 30 minutes before meals.After 4 weeks of treatment in all groups,the clinical symptoms,quality of life,anxiety and depression status and safety indicators were observed before and after the changes.The recurrence rate was counted 4 weeks after drug withdrawal to evaluate the clinical efficacy of the two groups.Results:1.The two groups were comparable in terms of gender,age and course of disease(P>0.05).2.The total scores of TCM symptoms and the scores of various TCM symptoms of the two groups of patients were comparable(P>0.05).In the comparison of the total TCM symptom scores,the total TCM symptom scores of the two groups of patients after treatment were significantly lower than it before treatment(P<0.05),and the decline in the treatment group was much higher than that of the control group(P<0.05).In the comparison of various TCM symptom scores.after treatment,the scores of various TCM symptoms of the two groups of patients were significantly lower than those before treatment(P<0.05),and the scores of the four symptoms of postprandial satiety,early satiety,nausea and vomiting,acid reflux in the treatment group were significantly lower than those in the control group(P<0.05).3.Before treatment,there was no statistically significant difference in the overall quality of life and the quality of life in each field between the two groups of patients(P>0.05).In the overall quality of life comparison,the overall quality of life of the two groups of patients after treatment was significantly improved compared with that before treatment(P<0.05),and the improvement in the treatment group was higher than that of the control group(P<0.05).In the comparison of quality of life in various fields,the quality of life in all areas of the treatment group after treatment was higher than that before treatment,and the quality of life in the control group in the areas of daily activities,worry,discomfort,disease control,and stress was higher than before treatment(P<0.05).And the quality of life of the treatment group in the areas of daily activities,anxiety,health perception,disease control,and stress was significantly higher than that of the control group(P<0.05).4.By comparing HAMA anxiety scale and HAMD depression scale,it can be found that the two groups are comparable in the changes of anxiety and depression(P>0.05).After treatment,the anxiety score and depression score of the two groups of patients were significantly lower than before treatment(P<0.05),and the reduction of anxiety score and depression score of the treatment group was greater than that of the control group(P<0.05).5.We followed up the two groups of patients 4 weeks after stopping the drug.A total of29 people in the treatment group were followed up,5 of whom relapsed,with a recurrence rate of 17.24% and a total of 24 people in the control group were followed up,13 of whom relapsed,with a recurrence rate of 54.17%(P<0.05).6.There were no adverse reactions in the two groups of patients during the study.Conclusion: Sijunzi decoction combined with Baohe pill is safe and effective in treating PDS with spleen deficiency and qi stagnation.It is better than mosapride citrate dispersible tablets in improving patients’ clinical symptoms,improving patients’ quality of life,relieving patients’ anxiety and depression,and controlling disease recurrence.It is worthy of clinical promotion.