| Objective: The purpose of this study was to observe the clinical effect of Xiangsha Yangwei Pills on postprandish discomfort syndrome(syndrome of spleen deficiency Qi stagnation and dampness).Methods: In this study,a total of 120 patients diagnosed as postmeal discomfort syndrome(syndrome of spleen deficiency and Qi stagnation and dampness)in the Department of Spleen,Stomach and Liver Diseases of Hunan Hospital of Integrated Traditional Chinese and Western Medicine from December 2020 to January 2023 were collected and randomly divided into treatment group,western medicine control group and blank control group,40 cases each.The treatment group was given Xiangsha Yangwei pills,the western medicine control group was given domperidone,and the blank control group was given Xiangsha Yangwei pills placebo.The treatment course was 4 weeks.To observe the clinical effect of Xiangsha Yangwei Pills on postmeal discomfort syndrome syndrome of spleen deficiency and qi stagnation and dampness by comparing the total Western symptom score,TCM syndrome effect,TCM symptom score,Hamilton Anxiety Scale score,Hamilton Depression Scale score and recurrence rate of three groups.SPSS software was used for statistical analysis of the research results.Results: 1.Total symptom score of Western medicine: the total symptom score of three groups decreased after treatment and the difference was statistically significant compared with that before treatment(P<0.05);Further pairwise comparison showed that there was no statistical significance between the treatment group and the western medicine control group(P>0.05),while the treatment group and the Western medicine control group were respectively compared with the blank control group,and the difference was statistically significant(P<0.05).The results showed that all three groups were effective after treatment,and the therapeutic effect of the treatment group and the western medicine control group was similar,and both were better than the blank control group.2.Curative effect of TCM syndrome: The total effective rate of the treatment group was 77.5%.The total effective rate of the western control group was 75%,and that of the blank control group was 27.5%,indicating that the curative effect of the treatment group was the best(P<0.05).3.Comparison of TCM symptom score:(1)The total score of TCM symptoms in the three groups decreased after treatment and the difference was statistically significant compared with that before treatment(P<0.05).Further ppair comparison showed that there was no statistically significant difference between the treatment group and the western medicine control group(P>0.05),while there was statistically significant difference between the treatment group and the Western medicine control group and the blank control group(P<0.05).The results showed that all three groups were effective after treatment,and the therapeutic effect of the treatment group and the western medicine control group was similar,and both were better than the blank control group.(2)Comparison of single symptom scores: After treatment,the symptoms of postpranational distension,early satiety,low satiety,belching,fatigue,heavy body drowsiness,loose stool and so on could be improved in the three groups to varying degrees.The clinical efficacy of the treatment group was similar to that of the western medicine control group in postprantal fullness,early satiety and belching(P>0.05),and was superior to that of the blank control group(P<0.05).The efficacy of the treatment group was better than that of western medicine control group and blank control group(P<0.05),and the western medicine control group was better than blank control group(P<0.05).The treatment group was superior to western medicine control group and blank control group in improving mush weight and loose stool(P<0.05),and the therapeutic effect of western medicine control group and blank control group was similar(P>0.05).These results indicated that the treatment group had an obvious advantage in improving the symptoms of fatigue,body drowsiness,loose stool and other wet drowsiness.4.Hamiltonian Anxiety Scale Scores:(1)In the aspect of the total score of Hamilton anxiety scale: the total score of the treatment group after treatment was the lowest(P<0.05).(2)Somatic anxiety score: After treatment,the treatment group had the lowest score(P<0.05);There was no significant difference between western medicine control group and blank control group(P>0.05).(3)Mental anxiety score: There was no significant difference in mental anxiety score among the three groups after treatment(P>0.05).This indicated that the treatment group reduced the total score of the anxiety scale by reducing the somatic anxiety score.5.Hamilton Depression Scale Score: After treatment,the treatment group had the lowest scores in total score,somatic anxiety level,gastrointestinal symptom level and systemic symptom level(P<0.05).The scores of somatic anxiety and gastrointestinal symptoms in western medicine control group were lower than those in blank control group,and the difference was statistically significant(P<0.05).There was no significant difference in total score and symptom score between western medicine control group and blank control group(P>0.05).The results showed that the treatment group was better than the other two groups in improving the overall depression,somatic anxiety,gastrointestinal symptoms and systemic symptoms.The western medicine control group was superior to the blank control group in improving somatic anxiety and gastrointestinal symptoms,but had no obvious advantage in improving overall depressive symptoms and systemic symptoms.6.Recurrence rate: three months after treatment,the number of effective patients in the treatment group was 31,8 cases of relapse,recurrence rate was25.8%;The total number of effective patients in the control group of western medicine was 30 cases,19 cases of relapse,recurrence rate was 63.3%.The total number of effective patients in blank control group was 11 cases,9 cases relapsed,and the recurrence rate was 81.8%.The results indicated that the recurrence rate of the treatment group was the lowest and the long-term curative effect was good(P<0.05).Conclusion: Xiangsha Yangwei Pills have significant curative effect in the treatment of postprandish discomfort syndrome(syndrome of spleen deficiency and Qi stagnation and dampness),which can not only improve the clinical symptoms of patients,but also relieve the anxiety and depression of patients.No adverse reactions occurred,and the long-term curative effect is good. |
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