| Objective: To observe the clinical effect and safety of Chaige Yinqiao Powder on the treatment of 3-14 year old children with epidemic cold fever and lung syndrome by randomly controlled clinical method,and provide scientific and reliable evidence for diagnosis and treatment of children influenza.Methods: the influenza children from December 2019 to December 2020 were selected from the pediatric clinic of Affiliated Hospital of Gansu University of traditional Chinese medicine.The results of detection of influenza virus antigen in nasopharynx swabs or swabs were positive and the syndrome differentiation of TCM was heat virus attack lung syndrome.78 children with influenza fever and lung syndrome who met the inclusion and did not meet the exclusion criteria were randomly divided into the experimental group and the control group,39 patients respectively.The experimental group was treated with Chaige Yinqiao Powder and the control group was treated with oseltavir phosphate granules.The treatment cycle of the two groups was 5 days.The TCM symptom score(fever,head and body pain,cough,runny,pharyngitia)before and after treatment were observed and recorded.The time of symptom relief,blood routine values(white blood cell number,neutrophil percentage and lymphocyte percentage)before and after treatment were recorded.Detection results of influenza A/B virus antigen in two groups after treatment,and the liver and kidney function indexes(ALT,AST,Scr,BUN)were measured before and after treatment.The data of the software spss25.0 were used to analyze and calculate the adverse reactions of glutaraldehyde,creatinine,urea nitrogen,adverse drug reactions,etc.Results: 78 cases of the patients with epidemic cold and fever attack lung syndrome were included in this study.During the treatment,the experimental group stopped and shed 3cases: 2 children refused to take Chinese medicine on time,1 case had mesenteric lymph node swelling and took antibiotics by themselves;control group stopped and dropped out 3 cases: 1case with bacterial pneumonia,1 case with mycoplasma pneumonia,1 case with mycoplasma pneumonia,1 case with mycoplasma pneumonia refused to use western medicine only.Finally 72 children completed the treatment plan,and the data were included in statistical analysis,36 cases in the experimental group and the control group respectively.1.baseline analysis and comparison before entering the group: before treatment,the difference was no statistical significance and comparability was found by comparing the two groups of children’s sex,age,TCM syndrome score,blood routine value(WBC,N%,L%),liver and kidney function index(ALT,AST,Scr,BUN).2.the comparison between the two groups of TCM syndrome score group: the scores and total scores of TCM before and after treatment in the experimental group and observation group were compared in the group,P value was less than 0.05,the difference was statistically significant.3.comparison between the two groups of TCM syndrome score: after treatment,the results showed that the P value of fever,pharyngitia and total score P was less than 0.05,the difference was statistically significant;the difference between the scores of head and body pain,cough and running nose was not statistically significant(P > 0.05).4.the overall efficacy comparison: the more obvious rate of the experimental group was80.56%,the effective rate was 91.67%;the more obvious rate of the control group was55.56%,the effective rate was 83.33%.The results of rank sum test showed that the difference of the treatment effect between the two groups was statistically significant(P <0.05).5.comparison of main symptom relief time: the time of symptom relief of fever,head and body pain,cough,runny and pharyngitis in the experimental group and control group was compared.P value was less than 0.05,indicating that the difference was statistically significant.6.comparison between the two groups of blood routine values: the results showed that there was no statistical significance in WBC values(P > 0.05),and the difference between N and L% was statistically significant(P < 0.05)7.the comparison between the two groups of blood routine values(WBC,N%,L%): the WBC values of the experimental group and the control group were compared,P > 0.05,and there was no statistical significance;the difference was statistically significant compared with the values of N% and L%,P < 0.05.8.comparison of the negative rate of influenza virus antigen detection between the two groups: the negative rate of influenza virus antigen detection in the experimental group was91.67%,and that in the control group was 72.22%,the difference was statistically significant(P < 0.05).9.the comparison of liver and kidney function between the two groups(ALT,AST,Scr,BUN):(1)the values of ALT,AST,Scr and BUN were compared before and after treatment,P > 0.05,and the difference was not statistically significant;(2)after the treatment,the values of ALT,AST,Scr,BUN were all > 0.05,and the difference was not statistically significant.10.the adverse reactions of the two groups were compared: one of the children in the experimental group had slight nausea and vomiting,which was not relieved by the drug itself;in the control group,one case had diarrhea,and the diarrhea symptoms were eliminated after two days of treatment with clostridium caseinate active bacteria powder.The difference was not statistically significant when P > 0.05 by chi square test.Conclusion: Chaige Yinqiao Powder has a significant clinical effect on the children with fever and lung syndrome influenza,and has a high safety.Chaige Yinqiao Powder can improve the fever,pharyngeal pain and overall symptoms of influenza children more effectively than ostavir phosphate.The more obvious and effective rate of the treatment of fever,body pain,cough,runny and pharyngitis in the group of Chaige Yinqiao Powder are higher than that of oseltamivir phosphate group,and the time of relieving fever,head and body pain,cough,runny and pharyngeal pain is significantly shortened;Compared with oseltamivir phosphate,Chaige Yinqiao Powder can significantly increase N% and decrease L%.The results showed that the detection rate of influenza virus antigen in Chaige Yinqiao Powder group was significantly higher than that of the control group after treatment.Neither Chaige Yinqiao Powder group nor oseltavir phosphate group had significant damage to the liver and kidney function of influenza children,both of which were safe. |
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