Chaige Jieji Decoction Combined With Oseltamivir In The Treatment Of Children Clinical Research On Influenza(External Cold And Internal Heat Syndrome)

Objective: To observe the clinical efficacy of Chaige Jieji Decoction combined with oseltamivir in the treatment of infantile influenza(superficies cold and interior heat syndrome),and to explore the effectiveness and safety of integrated chinese and western medicine in the treatment of infantile influenza.Methods: Cases were collected from November 2019 to January 2020.All cases were from the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine.The patients were screened to meet the diagnostic criteria of influenza in western medicine and superficies cold and interior heat syndrome of TCM.70 patients were randomly divided into experimental group(n=35)and control group(n=35).The experimental group was treated with Chaige Jieji Decoction combined with oseltamivir,and the control group was treated with oseltamivir.The course of treatment in this study was 5 days.The child’s first visit was taken as the first day of treatment,and the child’s body temperature and TCM syndrome were recorded.During treatment,take the body temperature and record every 6 hours,and take CARIFS score every 24 hours and record the score.The outpatient visit was performed on the 3rd and5 th day of treatment to observe the incidence of complications,record and evaluate the TCM syndrome,summarize and evaluate the body temperature records and CARIFS score records during the treatment period.Using the complete antipyretic time,clinical recovery time,TCM syndrome efficacy,TCM syndrome score changes,and complication rate as the effectiveness evaluation indicators and taking clinical adverse reactions as safety evaluation indicators.Results: The parent of one child in the experimental group refused to continue the medication,and the parent of one child in the control group used illegal drugs related to influenza treatment,all of which were dropped cases.1.At the end of treatment,the median time(hours)for complete fever reduction in the two groups of children were 36.00 and 48.00,respectively,and the difference was statistically significant,indicating that the experimental group can promote complete fever reduction in children more quickly.2.At the end of treatment,the median clinical recovery time(days)of the two groups of children were both 3.00.Considering that the average rank of the experimental group was less than the control group,and the difference was statistically significant,indicating that the experimental group could promote faster the child recovered.3.After 3 days of treatment,the total effective rate of TCM syndromes in the experimental group and the control group was both 100.00%,but the significant rate(91.18%)of the experimental group was significantly higher than that of the control group(52.94%),and the difference was statistically significant.After 3 days of treatment,the efficacy of TCM syndrome in the experimental group was more significant;after 5 days of treatment,the total effective rate of TCM syndrome in the experimental group and the control group was both100.00%,but the recovery rate of the experimental group(52.94%)was significantly higher than that of the control group(26.47%)),and the difference between the two groups was statistically significant,indicating that the therapeutic effect of TCM syndrome in the experimental group was more obvious after 5 days of treatment.4.After 3 days of treatment,the two groups were compared within the group and found that the main symptoms,secondary symptoms,total scores and TCM single syndrome scores were statistically significant;Comparison between groups showed that the scores of main and secondary symptoms and TCM single syndrome had statistical significance.The scores of headache and muscle soreness were compared between the two groups P < 0.01.The results showed that TCM syndromes in both groups were significantly improved after 3 days of treatment.Compared with the two groups,the experimental group improved the TCM syndromes more obviously,and improved the headache and muscle soreness more significantly.5.After 5 days of treatment,the two groups were compared within the group and found that: main symptoms,secondary symptoms,total scores and TCM single syndrome scores were statistically significant;comparison between groups found: main symptoms,TCM single syndrome scores(except cough,Burnout)were not statistically significant,secondary symptoms,total scores,cough score and burnout score were statistically significant,indicating that the TCM syndrome in the two groups were significantly improved after 5 days of treatment;Both groups had the same effect in improving the main symptoms and TCM syndromes(except cough,Burnout),and the improvement of cough and burnout was more obvious in the experimental group.6.The incidence of complications in both groups was 0.Conclusion: The clinical study of Chaige Jieji Decoction combined with oseltamivir in the treatment of infantile influenza(superficies cold and interior heat syndrome)shows that the experimental group is better than the control group in terms of shortening the time of complete fever reduction and clinical recovery time,and the efficacy of TCM syndromes.It was better than the control group in improving single TCM syndrome After 3 days of treatment,and it was effective in improving headaches and muscle soreness;at 5 days of treatment,it was better than the control group in improving cough and fatigue.There were no complications,adverse reactions or serious adverse events in the two groups.In summary,the combination of Chaige Jieji Decoction and oseltamivir has good clinical effectiveness and safety,and is worthy of extensive clinical application.