Research On The Regularity Of Clinial Use In The Treatment Of Idiopathic Membranous Nephropathy By Professor Peiqing Zhang

Objective: This subject retrospectively analyzes the clinical data of 74 patients with idiopathic membranous nephropathy,observes and evaluates the efficacy and safety of Professor Zhang Peiqing’s clinical treatment of idiopathic membranous nephropathy.Based on the v2.5 system of the TCM Inheritance Auxiliary Platform,in-depth excavation of the tutor Professor Zhang Peiqing’s clinical medication rules for the treatment of IMN based on syndrome differentiation provides more effective diagnosis and treatment plans and TCM drug guidance for clinical treatment of idiopathic membranous nephropathy..Methods: From January 2019 to December 2019,74 patients with nephropathy who were diagnosed with idiopathic membranous nephropathy through renal biopsy were selected from the second,seventh,and eighth kidney departments of the Heilongjiang Provincial Hospital of Traditional Chinese Medicine.Through retrospective analysis of research methods,74 patients with idiopathic membranous nephropathy who met the inclusion criteria were observed for clinical efficacy.After 6 months of treatment,through self-control methods,we observed the relevant laboratory indicators and traditional Chinese medicine before and after treatment.The changes of syndromes are analyzed statistically to evaluate the treatment effect;and based on the v2.5 system of the auxiliary platform of traditional Chinese medicine inheritance,the research on the clinical medication law of Professor Zhang Peiqing in the treatment of idiopathic membranous nephropathy is analyzed and explored..Results:1.Clinical efficacy:(1)The 24 h urine protein quantitative comparison between before treatment and after 6months of treatment showed that the 24 h urine protein quantitative after 6 months of treatment decreased compared with that before treatment,and the difference was statistically significant(P< 0.01).(2)Plasma albumin increased after 6 months of treatment compared with that before treatment,and the difference was statistically significant(P<0.05).After 6 months of treatment,total cholesterol,triglycerides,and low-density lipoprotein decreased compared with those before treatment,and the difference was statistically significant(P<0.05).After 6months of treatment,serum creatinine,blood urea nitrogen,alanine aminotransferase,aspartate aminotransferase,and glutamyl transpeptidase were not significantly different from those before treatment(P>0.05).2.Symptoms and efficacy: After 6 months of treatment,the TCM syndromes were significantly improved,and compared with before treatment,the difference was statistically significant(P<0.01).3.Medication rule: There are 382 prescriptions,134 medicines,and 6242 medications.According to statistics,there are 30 traditional Chinese medicines that have been used more than 40 times.According to the frequency of use,the order is: Astragalus> Codonopsis>Oldenlandia diffusa> Chinese yam> Golden cherry seed> Smilax chinensis> Coix seed>Achyranthes bidentata> Licorice> Scutellaria barbata> Mulberry>Poria cocos>Dodder>Goji berry>Plantaceae>Atractylodes Rhizome>Gorgon>Imperata cylindrica Root>Leonurus vulgaris>Panshanlong>Dogwood>Alisma lucidum>Bupleurum>Angelica>Salvia>Ligustrum lucidum>Peony skin>Digu skin>Rehmannia glutinosa> Ophiopogon japonicus.From the analysis of the proportion of drug efficacy,the number of tonic drugs appeared 28 times,accounting for 20.90%,which accounted for the highest proportion;followed by the appearance of antidampness drugs 23 times,accounting for 17.16%;The number of occurrences of medicine was 19 times,accounting for 14.18%;the number of occurrences of promoting blood circulation and removing blood stasis medicine was 13 times,accounting for 9.70%;the number of occurrences of receiving astringent medicine was 8 times,accounting for 5.97%.The frequency of cold medicines,flat medicines,warm medicines,cold medicines,and hot medicines are: 36.57%,26.87%,30.60%,3.73% and 2.24%.Among them,cold medicines are used most frequently,and warm medicines Medicine comes next.4.During the course of treatment,11 cases of adverse events occurred,accounting for14.86%.5.The pathological stage is mainly stage II,and there is no statistical difference between different pathological stages,age and TCM syndrome types Academic significance(P>0.05).Conclusion:1.The treatment of idiopathic membranous nephropathy with traditional Chinese medicine combined with western medicine can reduce proteinuria,increase plasma albumin,stabilize renal function,anticoagulation and lipid regulation,improve edema,edema,fatigue and other clinical symptoms,especially in systemic treatment of 6 Months later,the curative effect was remarkable,and no serious adverse reactions were found.2.Among Professor Zhang Peiqing’s clinical common treatment plans for idiopathic membranous nephropathy,the treatment plan of TCM syndrome differentiation + hormone +cyclophosphamide is the most used,and the overall remission rate is higher than other treatment plans.Among them,the TCM syndrome differentiation is based on the spleen Kidney deficiency and damp-heat internal type are the most common,Qi and Yin deficiency,damp-heat internal type is the next.TCM syndrome differentiation and treatment is the most used prescription for nephritis and whitening modified by Professor Zhang Peiqing,followed by Qingxinlianziyin.