Clinical Study On The Effect Of Feixinning Capsule On Lung Function In Patients With COPD Complicated With Right Heart Failure Based On "treatment Of Lung Disease From The Middle Jiao"

Objective:To observe the clinical efficacy of Feixinning capsule in the treatment of COPD complicated with right heart failure（phlegm heat syndrome）,and to provide theoretical and clinical basis for Feixinning capsule in the treatment of this disease.Methods:120 patients with COPD complicated with right heart failure（phlegm heat syndrome）in the outpatient and inpatient department of traditional Chinese Medicine Hospital of Inner Mongolia Autonomous Region from July 2018 to September 2020were selected as the observation objects,and the randomized,controlled and single blind clinical trial design method was adopted.The patients were randomly divided into the experimental group and the control group by the computer random method.A total of 113 patients were included,and 57 patients in the experimental group 56 cases in the control group.The control group was given conventional western medicine treatment,and the experimental group was given Feixinning Capsule on the basis of conventional western medicine treatment.The course of treatment was 8 weeks.The first drug delivery,4 weeks and 8 weeks were taken as the observation nodes.The TCM syndrome score,lung function,blood gas analysis,cat score,six minute walk test and the number of acute exacerbations in half a year were observed in the two groups,and then the effect of Feixinning Capsule on the prognosis was evaluated The clinical efficacy of the capsule was evaluated.result:1.Comparison of clinical efficacy between the two groups:the total effective rate of the experimental group was 72.0%,the marked effective rate was 21.1%,the effective rate was 50.9%;the total effective rate of the control group was 35.7%,the marked effective rate was 10.7%;the effective rate was 25.0%;the comparison between the two groups showed that the effect of the experimental group was better than that of the control group,the difference was statistically significant（P<0.05）.2.Comparison of lung function between the two groups:intra group comparison,the predicted values of FEV₁/FVC and FEV₁%after 8 weeks of treatment in the two groups were better than those before treatment,the difference was statistically significant（P<0.05）;inter group comparison,the improvement of the predicted values of FEV₁/FVC and FEV₁%in the experimental group was better than that in the control group,the difference was statistically significant（P<0.05）.3.Comparison of blood gas analysis between the two groups:repeated measurement analysis of variance showed that Pa O₂and Pa CO₂of the two groups changed with the change of time factors,with statistical significance（P<0.05）;different treatment methods at the same time could make differences in Pa O₂and Pa CO₂,with statistical significance（P<0.05）;Pa O₂at different time points was caused by different treatment methods The difference was not statistically significant（P>0.05）;Pa CO₂at different time points was different due to different treatment methods,and the difference was statistically significant（P<0.05）.4.Comparison of cat scores between the two groups:repeated measurement ANOVA showed that cat scores of the two groups changed with the change of time factors,with statistical significance（P<0.05）;different treatment methods at the same time could make differences in cat scores,with statistical significance（P<0.05）;cat scores at different time points were different due to different treatment methods The difference was statistically significant（P<0.05）.5.Comparison of six minute walking distance（6MWD）between the two groups:repeated measurement analysis of variance showed that 6MWD of the two groups changed with the change of time factors,with statistical significance（P<0.05）;different treatment methods at the same time could make the difference of 6MWD,with statistical significance（P<0.05）;6MWD at different time points was caused by the difference of treatment methods The difference was statistically significant（P<0.05）.6.Comparison of TCM syndrome scores between the two groups:the repeated measurement analysis of variance showed that the total TCM syndrome scores and their scores of the two groups changed with the change of time factors,with statistical significance（P<0.05）;at the same time,different treatment methods can make the total TCM syndrome scores and their scores（except the lung system scores）of the two groups have statistical significance Statistical significance（P<0.05）;at the same time,there was no significant difference in the lung system score under different treatment methods（P>0.05）;the total score of TCM syndrome and its various scores at different time points were different due to the difference of treatment methods,and the difference was statistically significant（P<0.05）.7.Comparison of the number of acute exacerbations in half a year between the two groups:the number of acute exacerbations in the experimental group was significantly less than that in the control group,and the difference was statistically significant（P<0.05）.Conclusion:Based on the theory of"treating lung disease from the middle Jiao",the application of Feixinning capsule in the treatment of COPD combined with right heart failure（phlegm heat syndrome）has significant clinical effect,which can improve the lung function and blood gas analysis index of patients,improve the activity endurance,reduce the clinical symptoms,reduce the risk of acute exacerbation,and improve the quality of life of patients There was no obvious adverse reaction.