Study On The Correlation Between Cerebral Microbleeds And Cognition

Objective:A comprehensive neuropsychological test is conducted to explore the risk factors of cerebral microbleeds(CMBs),the relationship between the severity and location of CMBs with cognition.Methods: 52 cerebral small vessel patients with CMBs were recruited from October2019 and October 2020 in the People’s Hospital of Liaoning Province as case group.According to the location of CMBs divided into 3 groups:lobar group,deep or infratentorial group and mixed group.During the same period,40 patients were recurited as the control group that matched in age and education with the case group.All subjects underwent neuropsychological assessments of global cognition,immediate memory,short-term delayed memory,long-term delayed memory,recognition,attention/executive function,language and visual space.The results of neuropsychological assessment and their clinical data were recorded to analyze the association between CMBs and cognition.Results:1.There was no significant difference in age,education,vascular risk factors(hypertension,diabetes,hyperlipidemia,carotid plaque and stenosis),blood test and history of drug use between the CMBs group and without-CMBs group(number P<0.05).There are significant differences in male,smoking,drinking and CSVD imaging load(lacunar infarction and white matter lesions)between the CMBs group and the control group(number P<0.05).2.The comparison of neuropsychological assessment results showed that there was no significant difference in the immediate memory,recognition,inhibition of interference,language and visual space between the CMBs group and without-CMBs group(number P>0.05).There was significant difference in the global cognitive function,immediate and short-term delayed memory,attention,information processing speed and reasoning conversion between two groups(P < 0.05).3.The severity of CMBs is positively correlated with the severity of white matter lesions and lacunar infarction.4.The number of CMBs is negatively correlated with global cognition,memory and attention,which is also positively correlated with information processing speed,reasoning and conversion ability.After controlling the general information,it’s also correlated with memory and information processing speed.5.The score of global cognition,memory,attention,information processing speed and reasoning conversion ability in the lobar group are lower than those other groups.The score of attention in the deep or infratentorial CMBs group is lower than other groups(P < 0.05),but there is no significant difference in the global or other cognitive domains(P > 0.05).The mixed group has lower score of global cognition,memory,attention,information processing speed,reasoning and conversion ability(P < 0.05).Conclusion:The occurrence of CMBs is related to male,smoking and drinking.The severity of CMBs was positively correlated with the severity of white matter lesions and lacunar infarctione.CMBs is related to cognitive impairment and the number of CMBs is an independent factor of cognitive impairment,especially in memory and information processing speed.Mixed-CMBs has the most obvious damage to cognition,especially in memory,information processing speed and attention.Deep or infatentorial-CMBs only leads to attention impairment.