The Research Of The Intervention Of Kuanxiong Aerosol On Coronary Microcirculation And Anxiety-depressive State In Patients With Acute Myocardial Infarction After Percutaneous Coronary Intervention

ObjectiveThis experiment was designed to observe the intervention of Kuanxiong Aerosol on coronary microcirculation in patients with AMI which accepted PCI therapy and explore the effect of Kuanxiong Aerosol administered sublingually on coronary microcirculation and anxiety-depressive state in patients with AMI after PCI.MethodsWe will select 63 cases in patients who conformed to the AMI diagnosis and will undergoing emergency PCI therapy,then divide them randomly into the experimental group(32 cases)and the control group(31 cases).The control group: after the blood flow restore by balloon expansion,the infarct related artery would be given injection with 200μg nitroglycerin and treated by PCI.Standardized treatment was given according to the guidelines after surgery.The experimental group: on the basis of the treatment plan of the control group,patients will be given sublingually Kuanxiong Aerosol 3 sprays before PCI,and given sublingually Kuanxiong Aerosol 3 sprays/time,3 times a day for a course of 7 days besides the same treatment of the control group.The data of this two groups which would be observed and marked down are TIMI blood flow grade,corrected TIMI frame count(CTFC),myocardial blush grade of infarct related artery after PCI,high-sensitivity troponin Ⅰ(hs Tn Ⅰ),serum creatine phosphokinase(CK)and creatine phosphokinase isoenzyme(CK-MB)both peak and peak time,the changes of ST-T segment of ECG,and the TCM syndrome scoring curative effect,anxiety-depressive state(Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD)).Through the statistical analysis of the effect of Kuanxiong Aerosol on coronary microcirculation and its significance on clinical,we could obtain the result of difference between this two groups on the TCM and anxiety-depressive states effect.ResultsIn this study,a total number of 63 patients were included,which including32 in the experimental group and 31 in the control group.Patients in each group will be had a comparation among baseline data,clinical efficacy and safety,here are the result:1.There is no statistical difference(P>0.05)between this two groups in gender,age,vital signs on admission,history of smoking,history of hypertension,diabetes,infarct related artery distribution.2.There is no statistical difference(P>0.05)between this two groups in TIMI grade of blood flow,myocardial Blush grade,the changes of ST-T segment of ECG and high-sensitivity troponin Ⅰ(hs Tn Ⅰ),serum creatine phosphokinase(CK)and creatine phosphokinase isoenzyme(CK-MB)peak value and peak time.In terms of corrected TIMI frames(CTFC),the CTFC of the experimental group(10.96±3.27)is lower than CTFC of the control group(13.33±5.48),and the statistical difference is significant(P<0.05).3.There is no statistical difference(P>0.05)between this two groups’ patients on admission in the scores of TCM syndrome analysis.The scores of TCM syndrome analysis in the experimental group’s patients before discharge is lower than those in the control group,and the statistical difference is significant(P<0.05).There was no significant difference in the efficacy of TCM syndrome between the two groups(P>0.05).4.There is no statistical difference(P>0.05)between this two groups’ patients on admission in the scores of Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD).The scores of HAMA and HAMD in the experimental group’s patients before discharge is lower than those in the control group,and the statistical difference is significant(P<0.05).There was no significant difference in the efficacy of HAMA and HAMD between the two groups(P>0.05).5.In terms of major cardiovascular events MACE,the data of two groups have no statistical difference(P>0.05).The liver and the kidney function、white blood cell and platelet checking results before and after admission to hospital between the two groups have no statistical difference(P>0.05).Conclusion1.For patients with AMI,adding sublingually Kuanxiong aerosol on the basis of conventional PCI treatment can reduce CTFC and improve coronary microcirculation.2.Adding sublingually Kuanxiong aerosol on the basis of conventional Western medicine treatment can make better on improving patients’ TCM symptom scores.3.Adding sublingually Kuanxiong aerosol on the basis of conventional Western medicine treatment can make better on improving patients’ anxiety and depression scores.4.Adding sublingually Kuanxiong aerosol on the basis of conventional Western medicine treatment is not found to increase the risk of MACEs and adverse reactions.The scheme is safe and reliable for clinical use.