Clinical Study Of Treating Angina Pectoris Of Coronary Heart Disease With Kuanxiong Aerosol Based On Myocardial Energy Expenditure

Objective:To evaluate the clinical effect of Kuanxiong Aerosol(KA)on angina pectoris of coronary heart disease(CHD)based on myocardial energy expenditure(MEE).Methods:A total of 74 patients with coronary heart disease and angina pectoris who met the inclusion criteria were included,including 40 males and 34 females.According to the random number table,they were divided into the experimental group and the control group with 37 cases each.The experimental group was given sublingual spray of KA,and the control group was given sublingual spray of 0.9%sodium chloride solution of the same amount.Echocardiography was used to evaluate the changes in cardiac structure indexes of the two groups before and after intervention and calculate the level of MEE.The Comparison of Visual Analogue Scale(VAS)scores of the two groups before and after treatment were compared,and the changes in myocardial enzymes and high sensitivity cardiac troponin T(hs-cTnT)before and after treatment were checked to evaluate the clinical efficacy of KA.At the same time,the changes in blood and urine routine,liver and kidney functions and blood coagulation functions of the two groups before and after treatment were observed to evaluate the safety of KA.Results:1.Comparison of general conditions:the two groups of patients were evenly distributed in terms of sex and age,and follow-up comparisons were made.In addition,there was no significant difference between the two groups in the prevalence of hypertension,diabetes and other complications or the comparison of basic drug use(P>0.05).Most importantly,compared with the control group,the degree of coronary artery stenosis in the experimental group was P=0.961>0.05,with no statistical significance.2.VAS scores:The VAS scores of the experimental group before and after treatment were statistically significant(P<0.001).There was no significant difference in VAS scores before and after treatment in the control group(P=0.080).Moreover,the percentage difference in VAS scores between the two groups before and after treatment was also statistically significant(P<0.001).3.Comparison of myocardial enzyme and hs-cTnT:The levels of myocardial enzyme and supersensitive troponin T in the two groups showed no significant change before and after treatment,and the difference was not statistically significant(P>0.05).4.Comparison of heart size and structure:There was no significant difference between the two groups in comparison of cardiac structure indicators,P>0.05.In the experimental group,before and after treatment,the differences in aortic velocity time integral(VTI),left ventricular ejection time(LVET),and stroke volume(LVSV)were statistically significant(P<0.01).It can be seen that VTI and LVET were significantly shortened after treatment,LVSV decreases;However,there was no significant difference in the above indexes in the control group and in the circumferential end systolic wall stress(cESS)and left ventricular ejection fraction(EF)between the two groups before and after treatment(P>0.05).5.Comparison of MEE level:The difference in MEE level between the experimental group and the control group before treatment was not statistically significant(P=0.978>0.05),which was comparable.After treatment,the MEE in the experimental group decreased significantly compared with that before treatment(P<0.001);After treatment,the MEE in the control group had no significant change compared with that before treatment,and the difference was not statistically significant(P=0.551>0.05).6.Safety evaluation:There was no significant difference in blood pressure,heart rate,routine hematuria,liver and kidney function,or blood coagulation function between the two groups before and after treatment(P>0.05).7.Repeatability test of ultrasonic measurement indicators:Repeatability test of ultrasonic measurement indicators MEE and cESS showed that there was good correlation within and between observers,with ICC value>0.97.Conclusion:Kuanxiong Aerosol can safely and effectively improve the immediate symptoms of patients with coronary heart disease angina pectoris and reduce the level of myocardial energy consumption of patients with coronary heart disease angina pectoris.