Clinical Study On Treatment Of Gouty Arthritis In Stages With Prescriptions Of Yi Medical Agreement

Purpose:1.Watch the clinical validity and security of the staged cure of gouty arthritis(GA)prescribed by Yi doctors.2.Exploit the unique advantages of stubborn ethnic medicine to enrich the clinical research of Yi medicine in preventing and treating GA.3.To provide clinical basis for henceforth study of Yi medicine a cure of GA and It establish the base for the progress of Yi medicine for the cure of GA.Method:According to the inclusion criteria,120 instances of GA subjects in the acute phase and 120 instances of GA subjects in the intermission were gathered.Every stage apply the method of the RCT.The acute stage was subdivided into 60 subjects a therapy group(Miaofu Zhitong granules)and 60 subjects a control group(Autumn Narcissus tablets),medication for 5 days;the intermission was subdivided into 60 subjects in the therapy group(Xiezhuohuayu granules)and 60 subjects in the control group(benzbromarone tablets),medication for 12 weeks.Watch and write down the validity index(UA,ESR,CRP),liver and kidney function(AST,ALT,BUN,CR),blood routine(WBC),blood sugar(GLU),electrolytes(K~+,NA~+),Urine routine(urinary PH)and Yi syndrome points,etc.Then apply statistical approach to handle correlational data.Result:Acute phase:1.The therapy group and the control group as against around therapy.There were statistical discrepancy in ameliorating the integral of Yi syndromes and lowering the horizontal of UA,ESR and CRP(P<0.05).Contrasted with the control group,the therapy group ameliorated Yi syndrome integral were more remarkable efficacy(P<0.05),but in terms of lowering ESR and CRP horizontal,the control group was more evident efficacy(P<0.05).In terms of reducing UA horizontal,the two groups had similar curative effects(P>0.05).Contrasting the comprehensive efficacy of the two groups,the total valid rate of 93.3%in the control group was better than that in the therapy group 88.3%(P<0.05).2.The safety indicators(liver and kidney function,blood routine,blood glucose,electrolytes,urine routine)between the treatment group and the control group were not statistically different(P>0.05);but the control group There were more untoward reactions such as diarrhea,epigastric pain,and nausea than the therapy group(P<0.05).Intermittent stage:1.The around control of the therapy group showed statistical discrepancy in ameliorating Yi syndrome integral and reducing the horizontal of UA,ESR,and CRP(P<0.05),while the control group only had statistical discrepancy in lowering the horizontal of UA.(P<0.01),and without evident imparity in ameliorating Yi syndrome integral,lowering ESR and CRP horizontal(P>0.05).Contrasted with the control group,the therapy group lowered ESR and CRP horizontal more evident efficacy(P<0.05),but the control group reduced UA horizontal more remarkable(P<0.01),while the two groups were ameliorating The therapeutic effect on the syndrome integral is quite without statistical discrepancy(P>0.05).2.Post-treatment,the amount of acute recurrences of GA during intermission in the therapy group was visibly reduced Contrasted with the control group(P<0.05),but Contrasted with the control group,the UA≤360μmol/L compliance rate was lower than that of the control group(P<0.05).3..The safety indicators(liver and kidney function,blood routine,blood glucose,electrolytes,urine routine)between the treatment group and the control group were not statistically different(P>0.05);but the control group There were more untoward reactions such as diarrhea,epigastric pain,and nausea than the therapy group(P<0.05).In conclusion:1.Miaofu Zhitong Granules can availably remedy acute GA.It can lower inflammatory indexes(ESR,CRP)while ameliorating the symptoms of Yi medicine,and it is safer than the therapy of colchicine tablets.2.Xiezhuohuayu granules can well ameliorate intermission GA symptoms,inflammatory indexes(ESR,CRP)and UA horizontals,reduce the frequency of acute attacks,and have higher security than benzbromarone tablets.3.Yi medical agreement prescription staged therapy of GA has good validity and security,and it is worth to clinical study in the aftertime.