| Objectives By observing the difference of indexes before and after the treatment of invigorats the kidney blood circulation prescription in the treatment for polycystic ovary syndrome of kidney deficiency and blood stasis pattern,the clinical efficacy is evaluated,which provided a basis for further research and application.Methods The 62 patients with kidney deficiency and blood stasis polycystic ovary syndrome were randomly divided into treatment group and control group,31 cases per group,the control group was treated with Daying-35 and the treatment group was treated with Yishen Huoxue.After three menstrual cycles,to observe and record the body mass index,serum sex hormone level,bilateral ovarian volume by ultrasound,TCM syndrome score,menstrual score,acne score and safety data of the treatment group and control group before and after treatment,results was analysed by SPSS24.0 statistical software,to evaluate its clinical efficacy.Results This clinical trial finally included 62 qualified patients,General data(age,course of disease),TCM syndrome score,menstrual score,serum sex hormone,body mass index,ovarian volume of patients in the treatment group and control group before treatment were not statistically significant(P > 0.05).1 Clinical efficacy: After the treatment,there were no cured patients in both groups.In the treatment group,effective 7 cases,the efficiency is 22.58%;Effective 18 cases,the efficiency is 58.06%;Invalid 6 cases,Inefficiency is 19.35%.In the control group,effective 5 cases,the efficiency is 16.13%;Effective 20 cases,the efficiency is 64.52%;Invalid 6 cases,Inefficiency is 19.35%.2 The effect of TCM syndromes: The posttreatment and control groups were 83.87% and 51.61% respectively,better over the control group(P < 0.05).3 TCM syndrome score:Before and after treatment,Intra-group comparisons of treatment group and control group,the difference was statistically significant(P < 0.05).The TCM syndrome score in the treatment group was better than that in the control group(P < 0.05)after treatment.4 Menstrual score: After treatment,Intra-group comparisons of menstrual scores between the two groups have definite curative effect.After treatment,there was no significant difference between the two groups(P > 0.05).5 Serum sex hormone levels: testosterone(T),ratio of luteinizing hormone and follicle stimulating hormone(LH/FSH)in treatment group and control group were statistically significant(P < 0.05).Comparison of T between the two groups after treatment,the curative effect of the control group was better than that of the treatment group(P < 0.05).There was no significant difference in LH and LH/FSH between the two groups after treatment(P > 0.05)6 Ovarian volume:Intra-group comparison of ovarian volume between the two groups has definite effect(P < 0.05).Comparison of ovarian volume between the two groups after treatment was no statistical difference.7Body mass index: Before and after treatment,the difference between the two groups was statistically significant(P < 0.05),indicating that both groups could reduce the body mass index.After treatment,the control group decreased BMI better than the treatment group(P < 0.05).8 Acne score: Before and after treatment,there was significant difference between the two groups(P < 0.05);After treatment,there was no significant difference between the two groups(P > 0.05)9 Safety: no serious adverse events and adverse reactions occurred during the trial,before and after treatment,there was no significant difference in liver and kidney function(P > 0.05).Conclusions The clinical effect of Yishen Huoxue prescription in the treatment of polycystic ovary syndrome with kidney deficiency and blood stasis is clear,which is significantly better than Da Ying-35 in improving the clinical syndromes of traditional Chinese medicine,but the curative effect in reducing testosterone and body mass index of patients is lower than that of Da Ying-35.Figure0;Table 21;Reference 120... |
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