Efficacy,Safety Analysis And Prognostic Prediction Model Of Rt-PA Intravenous Thrombolysis In Patients With Acute Ischemic Stroke

Objective:Prognosis of 3 months after receiving recombinant tissue-type plasminogen activator(rt-PA)intravenous thrombolytic therapy for patients with acute ischemic stroke and without rt-PA intravenous thrombolytic therapy Investigate,explore the effectiveness and safety of rt-PA intravenous thrombolytic therapy,and construct a thrombolytic prognosis prediction model for patients with acute ischemic stroke,so as to provide reference for improving the prognosis of acute ischemic stroke patients and promoting rt-PA intravenous thrombolytic therapy.Methods:1.A total of 296 patients with acute ischemic stroke who were hospitalized in the Department of Neurology and Emergency Department of Jiangsu University Affiliated Hospital from June 2018 to March 2021 were continuously included,and a total of 106 patients agreed to receive rt-PA intravenous thrombolytic therapy.A total of 190 patients who failed to receive rt-PA intravenous thrombolytic therapy due to various reasons have completed the follow-up work after 3 months.The basic data of these patients were collected,the independent sample t test was used to process the measurement data,and the χ~2 test was used to process the count data to evaluate the prognosis of the patients after 3 months.2.Collect the basic data of a total of 106 patients with rt-PA intravenous thrombolytic therapy,use independent sample t-test to process measurement data,useχ~2 test to process count data,and use binary logistic regression analysis to calculate rt-PA in patients with acute ischemic stroke Independent predictors of the prognosis of intravenous thrombolysis,construct a reasonable predictive model.Results:1.In patients with acute ischemic stroke,the good prognosis rate of the rt-PA intravenous thrombolysis group was 60.4%,and the good prognosis rate of the rt-PA intravenous thrombolysis group was 47.9%.There was a statistical difference in the prognosis between the two groups.(χ~2=4.25,P<0.05).2.Patients with acute ischemic stroke received an increased risk of adverse events after intravenous thrombolysis with rt-PA(17% vs.10.5%),but there was no statistical difference between the two groups(χ~2=2.533,P>0.05).3.Gender,diabetes history,NHISS score,and low-density lipoprotein are independent predictors of the prognosis of rt-PA intravenous thrombolytic therapy for acute ischemic stroke.The constructed model has high sensitivity and specificity,and has certain clinical value.Conclusion:1.In patients with acute ischemic stroke,rt-PA intravenous thrombolytic therapy is safe and reliable,and the risk of adverse events will not increase.2.Gender,diabetes history,NHISS score,low-density lipoprotein can predict the prognosis of patients with acute ischemic stroke,and the prognosis is negatively correlated with female,diabetes history,NHISS score,and low-density lipoprotein.The order of importance is NHISS> low-density lipoprotein> gender>diabetes.