Treatment Of Refractory Auditory Hallucination In Schizophrenia With Risperidone And Amisulpride

ObjectiveTo explore the efficacy and safety of risperidone combined with amisulpride in the treatment of refractory auditory hallucination in schizophrenia.Research methodFrom August 2017 to November 2018,70 patients with schizophrenia who met the criteria for admission were randomly divided into experimental group and control group.35 patients in experimental group were treated with risperidone combined with amisulpride,and 35 patients in control group were treated with risperidone combined with placebo for 8weeks.Three time points(before treatment,at the 4th weekend of treatment and at the 8th weekend of treatment)were selected to evaluate the clinical efficacy with the Positive and Negative Symptoms Scale(PANSS),the Auditory Hallucination Scale(AHRS)and the General Assessment Scale(GAS).At the same time,side effects scale(TESS)was used to evaluate the adverse reactions of drugs.Result1.PANSS scale comparison: Before and after admission,the total score of PANSS scale,negative factor score,positive factor score and general psychiatric symptom score of the control group and the experimental group were compared within the group.The results showed that at the 4th and 8th weekends of the control group,the scores of PANSS scale decreased compared with those of the admission group.The statistical results showed that the difference was statistically significant(P < 0.05).At the 4th and 8th weekends of treatment,the scores of PANSS scale in the experimental group decreased significantly,and the statistical results showed that the difference was significant(P < 0.05).When comparing the total score,negative factor score,positive factor score and general psychiatric symptom score before treatment between the control group and the experimental group,the statistical results showed that there was no significant difference(P > 0.05),but there was no comparability between the experimental group and the control group at the fourth and eighth weekends of treatment,when comparing the experimental group with the control group,the changes of each score of the PANSS scale were significant.The results showed that the changes of experimental group values were more obvious,and the difference was statistically significant(P < 0.05).2.The results of GAS scale comparison showed that the scores of GAS scale in the control group increased compared with those before treatment at the 4th and 8th weekends of treatment,and the statistical results showed that there was significant difference(P <0.05);the scores of the experimental group increased significantly compared with those before treatment at the 4th and 8th weekends of treatment,and the changes of GAS scale scores showed that there was significant difference(P < 0.05).Before treatment,there was no significant difference in the scores of GAS scale between the control group and the experimental group,P > 0.05,and there was no comparability between the two groups.At the end of the eighth week,the changes of the scores of GAS scale between the control group and the experimental group showed a significant difference,P < 0.05,and the scores of GAS scale in the experimental group increased more significantly.3.AHRS scale score comparison: The results showed that the control group at the 4th and 8th weekends compared with the admission of the group,the AHRS scale scores decreased,the statistical results showed that there was a significant difference,P < 0.05;in the treatment to the 4th and 8th weekends,the experimental group AHRS scale scores decreased significantly,the statistical results showed that the difference was significant,P< 0.05.The AHRS scores of the control group and the experimental group before and after treatment were compared.The statistical results showed that there was no significant difference(P > 0.05)and there was no comparability.But at the end of the eighth week,the experimental group and the control group were compared.The results of the changes of the AHRS scores showed that there was a significant difference(P < 0.05),and the AHRS scores of the experimental group changed.The change is more obvious.4.Comparison of TESS Scale and Examination Indicators: Adverse drug reactions in the course of treatment were assessed by TESS scale.The most common adverse reactions were tremor,dystonia,menstrual disorder and dry mouth when compared between the experimental group and the control group.The statistical results of the scale showed that there was no statistical difference between the two groups after treatment,P > 0.05.Before treatment,there was no significant difference in body weight,biochemical test results,and QTC between the control group and the experimental group(P < 0.05).At the 8th weekend,the body weight,triglyceride and cholesterol of the experimental group were significantly higher than those of the control group(P < 0.05);at the 8th weekend,there was no significant difference in other indicators between the two groups,P > 0.05.Conclusion1.Risperidone combined with amisulpride is better than risperidone alone in the treatment of refractory hallucination in schizophrenia.2.Risperidone combined with amisulpride is more conducive to the recovery of social function in patients with schizophrenia.3.Risperidone combined with amisulpride is safer in the treatment of refractory auditory hallucination in schizophrenia.